Long-term Impact of Cardiorespiratory Fitness on Type 2 Diabetes Incidence: A Cohort Study of Japanese Men.
Long-term Impact of Cardiorespiratory Fitness on Type 2 Diabetes Incidence: A Cohort Study of Japanese Men.
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DOI：
10.2188/jea.je20170017
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发表时间：
2018-05-05
影响因子：
4.7
通讯作者：
Blair SN
中科院分区：
文献类型：
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作者：
Kawakami R;Sawada SS;Lee IM;Gando Y;Momma H;Terada S;Kinugawa C;Okamoto T;Tsukamoto K;Higuchi M;Miyachi M;Blair SN
我们试图研究心肺功能（CRF）和2型糖尿病发病率之间的关系，考虑到一个最长随访期为23年的日本男性队列的随访期。这项研究于1986年招募了7，804名无糖尿病的男性工人。使用踏车测力计测量CRF，并估计最大摄氧量。在1986年至2009年期间，参与者被随访2型糖尿病的发展，这是使用空腹血液测试，自我管理的问卷调查，或口服葡萄糖耐量测试后，从每年的健康检查尿液测试诊断。使用考克斯比例风险模型估计2型糖尿病发病率的风险比。在随访期间，1,047名男性患上了2型糖尿病。在按随访期的分析中（1986-1993年，1994-2001年和2002-2009年），在所有三个随访期，CRF与2型糖尿病的发生之间存在反向剂量反应关系（趋势P分别为0.019，<0.001和0.001），基线CRF与2型糖尿病发病率之间的相关性并没有随着随访时间的延长而减弱。与最低CRF组相比，发生2型糖尿病的危险比为0.69（95%置信区间[CI]，0.49-0.97）1986-1993年CRF最高组，0.57（95% CI，0.42-0.79），2002-2009年最高通用报告格式为0.47（95% CI，0.30-0.74）。高CRF与男性2型糖尿病发病率在>20年的延长期内较低的风险相关。
We sought to examine the association between cardiorespiratory fitness (CRF) and incidence of type 2 diabetes considering the follow-up period in a cohort of Japanese men with a maximum follow-up period of 23 years. This study enrolled 7,804 male workers free of diabetes in 1986. CRF was measured using a cycle ergometer, and maximal oxygen uptake was estimated. During 1986–2009, participants were followed for development of type 2 diabetes, which was diagnosed using fasting blood tests, self-administered questionnaires, or oral glucose tolerance tests after urinary tests from annual health checkups. Hazard ratios for the incidence of type 2 diabetes were estimated using Cox proportional hazards models. During the follow-up period, 1,047 men developed type 2 diabetes. In analyses by follow-up periods (1986–1993, 1994–2001, and 2002–2009), there was an inverse dose-response relationship between CRF and the development of type 2 diabetes for all three follow-up periods (P for trend 0.019, <0.001, and 0.001, respectively), and the association between CRF at baseline and the incidence of type 2 diabetes did not weaken with longer follow-up period. Compared with the lowest CRF group, hazard ratios of developing type 2 diabetes were 0.69 (95% confidence interval [CI], 0.49–0.97) for the highest CRF group in 1986–1993, 0.57 (95% CI, 0.42–0.79) for the highest CRF in 1994–2001, and 0.47 (95% CI, 0.30–0.74) for the highest CRF in 2002–2009. High CRF is associated with a lower risk of the incidence of type 2 diabetes over an extended period of >20 years among men.