Mechanisms of inflammation in gout.
Mechanisms of inflammation in gout.
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DOI：
10.1186/ar2952
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发表时间：
2010
影响因子：
4.9
通讯作者：
So A
中科院分区：
文献类型：
--
作者：
Busso N;So A
痛风的急性发作是急性无菌炎症的范例，而不是化脓性炎症。最近的研究表明，白细胞释放IL-1β的触发是一系列涉及多种细胞因子和介质的过程的核心。NLRP3炎性小体似乎在这方面具有特定的作用，但导致其激活的生化事件仍未得到很好的理解。我们回顾了尿酸盐晶体引发炎症过程的已知机制，并提出了需要进一步研究的领域。
An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation. Recent studies suggest that the triggering of IL-1β release from leucocytes lies at the heart of a cascade of processes that involves multiple cytokines and mediators. The NLRP3 inflammasome appears to have a specific role in this regard, but the biochemical events leading to its activation are still not well understood. We review the known mechanisms that underlie the inflammatory process triggered by urate crystals and suggest areas that require further research.