Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population.
Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population.
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DOI：
10.18632/oncotarget.6124
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发表时间：
2015-12-15
期刊：
影响因子：
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通讯作者：
Wei QY
中科院分区：
文献类型：
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作者：
Qiu LX;He J;Cheng L;Zhou F;Wang MY;Sun MH;Zhou XY;Li J;Guo WJ;Wang YN;Yang YJ;Wang JC;Jin L;Zhu XD;Wei QY
关于PRKAA 1 rs 13361707 T > C多态性与胃癌（GCa）易感性之间的关联的已发表数据尚不确定。为了更精确地估计这种关联，我们对1,124例病例和1,194例对照进行了一项大规模的GCa研究，以证实中国东部人群中的这种关联。我们的研究结果显示，PRKAA 1 rs 13361707的C等位基因在研究人群中增加了GC的风险[CT vs. TT，OR = 1.72，95%CI = 1.40-2.12; CC vs. TT，OR = 2.15，95%CI = 1.70-2.71; CT/CC与TT，OR = 1.86，95%CI = 1.53-2.26; CC与TT/CT，OR = 1.49，95%CI = 1.24-1.79]。此外，当按年龄、性别、肿瘤部位、饮酒和吸烟状态分层时，C等位基因与GCa风险增加的相关性在亚组中仍然显著。此外，本研究的结果通过我们进一步的荟萃分析得到了验证。总之，这些结果表明PRKAA 1 rs 13361707的C等位基因是GCa的低穿透风险因子。
Published data on the association between PRKAA1 rs13361707 T > C polymorphism and gastric cancer (GCa) susceptibility were inconclusive. To derive a more precise estimation of the association, we conducted a large-scale GCa study of 1,124 cases and 1,194 controls to confirm this association in an Eastern Chinese population. Our results showed that the C allele of PRKAA1 rs13361707 increased the GC risk in the study population [CT vs. TT, odds ratio (OR) = 1.72, 95% confidence interval (CI) = 1.40–2.12; CC vs. TT, OR = 2.15, 95%CI = 1.70–2.71; CT/CC vs. TT, OR = 1.86, 95%CI = 1.53–2.26; CC vs.TT/CT, OR = 1.49, 95%CI = 1.24–1.79]. In addition, the association of C allele with an increased GCa risk was still significant in subgroups, when stratified by age, sex, tumor site, drinking and smoking status. Moreover, the findings in the present study were validated by our further meta-analysis. In summary, these results indicated that the C allele of PRKAA1 rs13361707 was a low-penetrate risk factor for GCa.