Analysis of neural mechanisms underlying verbal fluency in cytoarchitectonically defined stereotaxic space - The roles of Brodmann areas 44 and 45
Analysis of neural mechanisms underlying verbal fluency in cytoarchitectonically defined stereotaxic space - The roles of Brodmann areas 44 and 45
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DOI：
10.1016/j.neuroimage.2003.12.031
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发表时间：
2004-05-01
期刊：
影响因子：
5.7
通讯作者：
Zilles, K
中科院分区：
文献类型：
--
作者：
Amunts, K;Weiss, PH;Zilles, K
我们研究了语言流畅性任务和布罗卡语言区（布罗德曼区44和45）的细胞结构概率图的神经激活。为此，我们重新分析了来自先前功能性磁共振成像（fMRI）[Brain 125（2002）10241]和来自细胞结构研究[J.Comp.Neurol. 412（1999）3191，并开发了一种方法来联合收割机组合两个数据集。在功能磁共振成像实验中，研究人员对11名健康志愿者的语言流畅性进行了研究，这些志愿者从预先定义的类别中秘密地产生单词。析因设计与因素口头类（语义与过度学习的流畅性）和类别之间的切换（否与是）。fMRI数据分析采用SPM99（Statistical Parameter Mapping）。44和45区的细胞结构图来自10个死后脑的组织切片。使用一种新的弹性变形工具将体内fMRI和死后MR数据变形到一个共同的参考脑。计算了两个区域的细胞结构概率图，并将其叠加在功能数据上，显示了左半球区域相对于基线的语言流畅性。语义相对于过度学习的流畅性表现出更大的参与左区45比44。因此，虽然这两个区域都参与了语言流畅性，但它们的作用是不同的。左侧区域45更多地涉及语言处理的语义方面，而区域44可能涉及编程语音产生本身的高级方面。功能数据分析与新的弹性变形工具和细胞结构图的结合为分析语言中涉及的皮层网络开辟了新的视角。(C)2004年爱思唯尔公司All rights reserved.
We investigated neural activations underlying a verbal fluency task and cytoarchitectonic probabilistic maps of Broca's speech region (Brodmann's areas 44 and 45). To do so, we reanalyzed data from a previous functional magnetic resonance imaging (fMRI) [Brain 125 (2002) 10241 and from a cytoarchitectonic study [J. Comp. Neurol. 412 (1999) 3191 and developed a method to combine both data sets. In the fMRI experiment, verbal fluency was investigated in 11 healthy volunteers, who covertly produced words from predefined categories. A factorial design was used with factors verbal class (semantic vs. overlearned fluency) and switching between categories (no vs. yes). fMRI data analysis employed SPM99 (Statistical Parametric Mapping). Cytoarchitectonic maps of areas 44 and 45 were derived from histologic sections of 10 postmortem brains. Both the in vivo fMRI and postmortem MR data were warped to a common reference brain using a new elastic warping tool. Cytoarchitectonic probability maps with stereotaxic information about intersubject variability were calculated for both areas and superimposed on the functional data, which showed the involvement of left hemisphere areas with verbal fluency relative to the baseline. Semantic relative to overlearned fluency showed greater involvement of left area 45 than of 44. Thus, although both areas participate in verbal fluency, they do so differentially. Left area 45 is more involved in semantic aspects of language processing, while area 44 is probably involved in high-level aspects of programming speech production per se. The combination of functional data analysis with a new elastic warping tool and cytoarchitectonic maps opens new perspectives for analyzing the cortical networks involved in language. (C) 2004 Elsevier Inc. All rights reserved.