Evaluation of malignancy and the prognosis of esophageal cancer based on an immunohistochemical study (p53, E-cadherin, epidermal growth factor receptor)
Evaluation of malignancy and the prognosis of esophageal cancer based on an immunohistochemical study (p53, E-cadherin, epidermal growth factor receptor)
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DOI：
10.1007/bf02482343
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发表时间：
1999-01-01
期刊：
影响因子：
--
通讯作者：
Iwashita, A
中科院分区：
文献类型：
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作者：
Inada, S;Koto, T;Iwashita, A
本研究的受试者包括40例术前未经治疗的食管鳞状细胞癌患者。p53与临床病理因素无明显相关性，E-cadherin与淋巴管浸润、血管浸润、浸润深度、淋巴结转移程度、组织学分期、淋巴结转移数有明显相关性，表皮生长因子受体（EGFR）与年龄、浸润深度、淋巴结转移数有明显相关性。p53阳性和阴性患者的5年累积生存率分别为45.7%和61.9%，差异无统计学意义; E-cadherin阳性和阴性患者的5年累积生存率分别为87.8%和19.1%，差异有统计学意义。EGFR阳性患者的预后明显较差：EGFR阳性患者的5年生存率为38.6%，EGFR阴性患者为68%。E-cadherin阴性EGFR阳性者5年生存率为0%，而E-cadherin阴性EGFR阳性者5年生存率为91.7%，两者之间有显著性差异。提示E-cadherin和EGFR均为重要的预后因素，两者联合应用可获得更准确的预后。这种联合技术可能是非常有用的指标，食管癌的生物学恶性程度分级。
The subjects in this study consisted of 40 preoperative untreated esophageal squamous cell carcinoma patients. While p53 did not significantly correlate with the clinicopathological factors, E-cadherin significantly correlated with lymphatic invasion, vascular invasion, the depth of invasion, the degree of lymph node metastasis, the histological stage, and the number of lymph node metastases, Epidermal growth factor receptor (EGFR) significantly correlated with age, the depth of invasion, and the number of lymph node metastases. The 5-year cumulative survival rate was 45.7% in the p53-positive cases and 61.9% in the p53-negative cases with no significant difference, and 87.8% in the E-cadherin-positive cases and 19.1% in the -negative cases, and the difference was significant. The prognosis was significantly poor in EGFR-positive subjects: the 5-year survival rate was 38.6% in EGFR-positive cases and 68% in -negative cases. The 5-year survival rate in E-cadherin-negative, EGFR-positive cases was 0%, while it was 91.7% in the reverse pattern, and this difference was significant, These findings suggest that both E-cadherin and EGFR are important prognostic factors, and a more precise prognosis can thus be obtained by combining them, Such a combined technique may be very useful as an indicator for grading the biological malignancy of esophageal cancer.