The association between aspirin use and the incidence of colorectal cancer in women
The association between aspirin use and the incidence of colorectal cancer in women
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DOI：
10.1093/aje/kwj250
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发表时间：
2006-09-15
影响因子：
5
通讯作者：
Kuller, Lewis
中科院分区：
文献类型：
--
作者：
Allison, Matthew;Garland, Cedric;Kuller, Lewis
本研究的目的是验证阿司匹林与降低结直肠癌发病率相关的假设。来自妇女健康倡议的91574名年龄在50岁到79岁之间的参与者在1993-1998年的基线上通过标准化问卷的访谈提供了阿司匹林使用的详细信息，随后在6年多的时间里每年对结直肠癌事件进行随访。对于那些报告使用阿司匹林的人，记录了化合物的类型、剂量和使用时间。在年度更新时，提示结直肠癌的病史由经过培训的当地医师审查员通过医疗记录和病理报告进行核实。有631例结肠癌或直肠癌的确诊病例。阿司匹林的使用与结直肠癌发生风险之间没有显著关联（风险比= 0.96,95%可信区间：0.8,1.2）。此外，在没有阿司匹林使用作为参考类别的情况下，阿司匹林摄入持续时间（< 1,1 -< 2,2 -< 3,3 -< 4,4 -< 5,>= 5年）或日剂量（< 165,165-< 300,300-< 495，或>= 495 mg）没有显著相关性。
The purpose of this study was to test the hypothesis that aspirin use is associated with a decreased risk of incident colorectal cancer. From the Women's Health Initiative, 91,574 participants between the ages of 50 and 79 years at baseline in 1993-1998 provided details on aspirin use via interview using a standardized questionnaire and were subsequently followed annually for incident colorectal cancer during a period of over 6 years. For those persons who reported aspirin use, the type of compound, dose, and duration of use were recorded. Medical histories suggestive of colorectal cancers at the annual update were verified by medical record and pathology report review by trained local physician adjudicators. There were 631 confirmed cases of invasive cancer of the colon or rectum. There was no significant association between any aspirin use and risk for incident colorectal cancer (hazard ratio = 0.96, 95% confidence interval: 0.8, 1.2). Moreover, with no aspirin use as the referent category, there were no significant associations for duration of aspirin intake by category (< 1, 1-< 2, 2-< 3, 3-< 4, 4-< 5, and >= 5 years) or for daily dosage by category (< 165, 165-< 300, 300-< 495, or >= 495 mg).