Risk of coronary heart disease and stroke in a large British cohort of patients with systemic lupus erythematosus
Risk of coronary heart disease and stroke in a large British cohort of patients with systemic lupus erythematosus
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DOI：
10.1093/rheumatology/keh213
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发表时间：
2004-07-01
期刊：
影响因子：
5.5
通讯作者：
Rahman, A
中科院分区：
文献类型：
--
作者：
Bessant, R;Hingorani, A;Rahman, A
Objectives. Patients with systemic lupus erythematosus (SLE) are at increased risk of myocardial infarction and stroke. We sought to determine how much of this risk was dependent on recognized cardiovascular risk factors.Methods. Initially a software package 'Cardio-Risk-Manager', which utilizes Framingham data, was used to calculate a 10-yr risk of coronary heart disease (CHD) and stroke for 202 patients with SLE (Group 1) in comparison with hypothetical age- and sex-matched comparators. Subsequently 47 patients who had been followed since 1991 (Group 2) were studied to compare their predicted risks in 1991 with the actual number of cardiovascular events that occurred during the subsequent decade.Results. Patients in Group 1 had a higher predicted 10-yr risk of stroke (P
