Vascular function is further impaired in subjects aged 80 years or older
Vascular function is further impaired in subjects aged 80 years or older
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DOI：
10.1038/s41440-020-0435-z
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发表时间：
2020-04-08
影响因子：
5.4
通讯作者：
Higashi, Yukihito
中科院分区：
文献类型：
--
作者：
Maruhashi, Tatsuya;Kajikawa, Masato;Higashi, Yukihito
在日本，80岁或以上的人口比例一直在上升。本研究的目的是探讨老年人群中血管功能与衰老之间的关系，并阐明80岁及以上人群血管功能的特点。我们测量了在广岛大学医院门诊就诊的737名60岁或以上的老年人的血流介导的血管扩张(FMD)、硝酸甘油诱导的血管扩张(NID)和臂踝脉搏波速度(BaPWV)。80岁及以上组FMD和NID显著低于60-69岁组和70-79岁组(分别为1.9+/-2.0%vs.2.9+/-2.6%和2.7+/-2.6%，P=0.008和P=0.03；8.6+/-5.1%vs.12.1+/-5.6%和11.2+/-5.5%，P<；0.001和P<；0.001)。年龄在80岁及以上的老年人较60~69岁的老年人和70~79岁的老年人显著升高(1978年±452 cm/S vs.1724±319 cm/S和1811±318 cm/S，P<；0.001和P<；0.001)。调整其他心血管危险因素后，80岁以上患者的FMD(OR2.0 2；95%CI1.19~3.4 2；P=0.0 1)、NID(OR3.6 2；95%CI2.13~6.17；P<；0.001)和BaPWV(OR3.48；95%CI1.99~6.0 8；P<；0.001)显著升高。血管功能，包括内皮功能、血管平滑肌功能和动脉僵硬，在80岁或80岁以上的受试者中显示出进一步的损害，这表明随着年龄的增长，血管功能在一生中继续受损。
The percentage of people aged 80 years or older in Japan has been increasing. The purpose of this study was to investigate the association between vascular functions and aging in the elderly population and to clarify the characteristics of vascular functions in subjects aged 80 years or older. We measured flow-mediated vasodilation (FMD), nitroglycerine-induced vasodilation (NID), and brachial-ankle pulse wave velocity (baPWV) in 737 subjects aged 60 years or older who visited the outpatient clinic at Hiroshima University Hospital. FMD and NID were significantly lower in subjects aged 80 years or older than in subjects aged 60-69 years or in subjects aged 70-79 years (1.9 +/- 2.0% vs. 2.9 +/- 2.6% and 2.7 +/- 2.6%,P = 0.008 andP = 0.03, respectively and 8.6 +/- 5.1% vs. 12.1 +/- 5.6% and 11.2 +/- 5.5%,P < 0.001 andP < 0.001, respectively). baPWV was significantly higher in subjects aged 80 years or older than in subjects aged 60-69 years or in subjects aged 70-79 years (1978 +/- 452 cm/s vs. 1724 +/- 319 cm/s and 1811 +/- 318 cm/s,P < 0.001 andP < 0.001, respectively). Age over 80 years was significantly associated with lower FMD (OR, 2.02; 95% CI, 1.19-3.42;P = 0.01), lower NID (OR, 3.62; 95% CI, 2.13-6.17;P < 0.001), and higher baPWV (OR, 3.48; 95% CI, 1.99-6.08;P < 0.001) after adjustment for other cardiovascular risk factors. Vascular functions, including endothelial function, vascular smooth muscle function, and arterial stiffness, were shown to be further impaired in subjects aged 80 years or older, suggesting that vascular functions continue to be impaired throughout life with aging.