Oscillatory Synchronization in Large-Scale Cortical Networks Predicts Perception
Oscillatory Synchronization in Large-Scale Cortical Networks Predicts Perception
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DOI：
10.1016/j.neuron.2010.12.027
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发表时间：
2011-01-27
期刊：
影响因子：
16.2
通讯作者：
Siegel, Markus
中科院分区：
文献类型：
--
作者：
Hipp, Joerg F.;Engel, Andreas K.;Siegel, Markus
正常的大脑功能需要功能专门化但广泛分布的皮层区域的动态相互作用。振荡信号的长距离同步被认为是在大规模皮层网络中介导这些相互作用的原因，但直接证据很少。在这里，我们表明，振荡同步是有组织的，在这样的大规模网络。我们实现了一种分析方法，允许同步皮层网络成像，并将这种技术应用于人类的EEG记录。我们发现了两个网络：额顶枕网络中的β-波段同步（类似于20 Hz）和中央-颞叶网络中的γ-波段同步（类似于80 Hz）。强大的感知相关支持他们的功能相关性：这些网络内的同步强度预测了受试者对模糊视听刺激的感知以及听觉和视觉信息的整合。我们的研究结果提供的证据表明，振荡神经元同步介导的频率特异性，大规模的皮层网络内的神经元通信。
Normal brain function requires the dynamic interaction of functionally specialized but widely distributed cortical regions. Long-range synchronization of oscillatory signals has been suggested to mediate these interactions within large-scale cortical networks, but direct evidence is sparse. Here we show that oscillatory synchronization is organized in such large-scale networks. We implemented an analysis approach that allows for imaging synchronized cortical networks and applied this technique to EEG recordings in humans. We identified two networks: beta-band synchronization (similar to 20 Hz) in a fronto-parieto-occipital network and gamma-band synchronization (similar to 80 Hz) in a centro-temporal network. Strong perceptual correlates support their functional relevance: the strength of synchronization within these networks predicted the subjects' percept of an ambiguous audiovisual stimulus as well as the integration of auditory and visual information. Our results provide evidence that oscillatory neuronal synchronization mediates neuronal communication within frequency-specific, large-scale cortical networks.