The Relationship Between Updated Sydney System Score and LDL Cholesterol Levels in Patients Infected with Helicobacter pylori
The Relationship Between Updated Sydney System Score and LDL Cholesterol Levels in Patients Infected with Helicobacter pylori
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DOI：
10.1007/s10620-008-0391-y
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发表时间：
2009-03-01
影响因子：
3.1
通讯作者：
Nazligul, Yasar
中科院分区：
文献类型：
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作者：
Kucukazman, Metin;Yavuz, Bunyamin;Nazligul, Yasar
目的幽门螺杆菌(Hp)慢性感染人体胃，可引起胃肠外疾病。幽门螺杆菌在动脉粥样硬化发病机制中的作用及其对血脂的影响仍存在争议。这项研究的目的是检测幽门螺杆菌感染患者和不感染幽门螺杆菌患者的血脂水平。方法244例接受食管胃十二指肠镜检查的患者为研究对象。接受他汀类和贝特类治疗的患者和糖尿病患者被排除在外。每个人的活检组织都被采集并分析，以进行超微结构方法的幽门螺杆菌检测。将患者分为两组：幽门螺杆菌(+)(组1)和幽门螺杆菌(-)(组2)。测定所有受试者的总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和甘油三酯水平。结果第1组共163例，第2组81例，H.第1组的总胆固醇(2 0 4+/-A39 mg/dl比189+/-A42 mg/dl；P=0.007)和低密度脂蛋白胆固醇(12 8+/-A30 mg/dl比116+/-A32 mg/dl；P=0.003)显著高于第2组。悉尼最新分级评分与低密度脂蛋白(r=0.333，P<0.0 1)和总胆固醇(r=0.288，P<0.0 1)呈正相关。结论幽门螺杆菌感染者血清总胆固醇和低密度脂蛋白胆固醇水平升高，悉尼系统最新评分与低密度脂蛋白胆固醇和总胆固醇水平呈正相关。这些发现可能解释了为什么幽门螺杆菌感染与动脉粥样硬化风险增加有关。
Objectives Helicobacter pylori (H. pylori) chronically infects the human stomach and may cause extra-gastrointestinal diseases. The role of H. pylori in the pathogenesis of atherosclerosis and its effect on lipids remains controversial. The aim of this study was to examine lipid levels in patients with and without H. pylori infection. Methods A total of 244 consecutive patients who underwent esophagogastroduodenoscopy were included in this study. Patients receiving statin and fibrate therapy and diabetic patients were excluded. Biopsies from each individual were taken and analyzed for H. pylori detection using ultrastructural methods. Patients were divided into two groups: H. pylori (+) (group 1) and H. pylori (-) (group 2). Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride levels were measured in all subjects. Results A total of 163 patients were included in group 1 and 81 patients were included in group 2. Frequency of H. pylori was 67% in the study population. Total cholesterol (204 +/- A 39 mg/dl versus 189 +/- A 42 mg/dl, respectively; P = 0.007) and LDL-C (128 +/- A 30 mg/dl versus 116 +/- A 32 mg/dl, respectively; P = 0.003) were significantly higher in group 1 than in group 2. Updated Sydney classification score showed a positive correlation with LDL-C (r = 0.333, P < 0.001) and TC (r = 0.288, P < 0.001) levels. Conclusion Increased levels of TC and LDL-C were found in patients infected with H. pylori, and updated Sydney System score showed a positive correlation with LDL-C and TC levels. These findings may explain why H. pylori infection is associated with increased risk of atherosclerosis.