Treatment of catatonia in autism spectrum disorders
Treatment of catatonia in autism spectrum disorders
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DOI：
10.1111/acps.12980
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发表时间：
2019-01-01
影响因子：
6.7
通讯作者：
Wachtel, L. E.
中科院分区：
文献类型：
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作者：
Wachtel, L. E.
目的回顾 22 名诊断为紧张症的自闭症患者 12 年的治疗过程，包括苯二氮卓类药物治疗和电休克治疗。方法 回顾性审查 22 名因紧张症接受神经行为服务的自闭症青少年的住院和门诊记录。结果 6 名女孩和 16 名男孩年龄从 8 岁到 26 岁，接受神经行为评估后发现符合 DSM5 的紧张症标准，并接受了治疗。除一名患者外，所有患者最初均接受每日 1 至 27 毫克剂量的苯二氮卓类药物治疗，但均未成功，所有患者均接受了电休克治疗。 ECT 开始的平均年龄为 15.6 岁，接受 ECT 的总数为 16 至 688 例，其中 13 名患者在研究期结束时仍在接受维持 ECT。 ECT 在减少紧张性症状方面给患者带来了显着的益处，包括减轻丧失能力、难治性的自伤。结论 在 22 名自闭症青少年样本中发现了多种紧张症症状。抗紧张症范例的实施，特别是电惊厥治疗，给患者带来了巨大的好处。
Objective To review the treatment courses of 22 autistic patients diagnosed with catatonia over a 12-year period, including treatment with benzodiazepines and electroconvulsive therapy. Method Retrospective review of inpatient and outpatient records of 22 autistic youth presenting to a neurobehavioral service who were treated for catatonia. Results Six girls and 16 boys ranging from ages 8 to 26 years old presenting for neurobehavioral assessment were found to meet criteria for catatonia according to the DSM5 and were treated for such. All but one patient was initially unsuccessfully treated with benzodiazepines in dosages ranging from 1 to 27 mg daily, and all patients underwent electroconvulsive therapy. Mean age of ECT start was 15.6 years old, and the total number of ECT received ranged from 16 to 688, with 13 patients still receiving maintenance ECT at the end of the study period. ECT conferred prominent patient benefit in terms of catatonic symptom reduction, including alleviation of incapacitating, treatment-resistant self-injury. Conclusion Myriad symptoms of catatonia were seen in this sample of 22 autistic youth. Implementation of anti-catatonic paradigms, particularly electroconvulsive therapy, conferred vast patient benefit.