Soft Hydrogels from Nanotubes of Poly(ethylene oxide) -Tetraphenylalanine Conjugates Prepared by Click Chemistry
Soft Hydrogels from Nanotubes of Poly(ethylene oxide) -Tetraphenylalanine Conjugates Prepared by Click Chemistry
复制标题
DOI：
10.1021/la8035659
复制
发表时间：
2009-02-17
期刊：
影响因子：
3.9
通讯作者：
Ryan, Anthony J.
中科院分区：
文献类型：
--
作者：
Tzokova, Nadia;Fernyhouph, Christine M.;Ryan, Anthony J.
通过炔烃修饰肽和叠氮化物封端的 PEO 低聚物之间的“点击”反应，制备了一种新的聚（环氧乙烷）-四苯丙氨酸聚合物-肽缀合物。这种聚合物-肽缀合物的 THF 溶液用水透析后形成自组装纳米管。这些纳米管的结构已通过圆二色性、IR、TEM 和 SAXS 进行了探测。从这些数据可以看出，自组装涉及反平行 β 片层和 pi-pi 堆积的形成。纳米管的形成浓度为 2 至 10 mg mL(-1)。相邻纳米管之间的缠结在较高浓度下发生，导致软水凝胶的形成。正如预期的那样，凝胶强度在聚合物-肽缀合物浓度较高时增加。
A new poly(ethylene oxide) -tetraphenylalanine polymer-peptide conjugate has been prepared via a "click" reaction between an alkyne-modified peptide and an azide-terminated PEO oligomer. Self-assembled nanotubes are formed after dialysis of a THF solution of this polymer-peptide conjugate against water. The structure of these nanotubes has been probed by circular dichroism, IR, TEM, and SAXS. From these data, it is apparent that self-assembly involves the formation of antiparallel beta-sheets and pi-pi-stacking. Nanotubes are formed at concentrations between 2 and 10 mg mL(-1). Entanglement between adjacent nanotubes occurs at higher concentrations, resulting in the formation of soft hydrogels. Gel strength increases at higher polymer-peptide conjugate concentration, as expected.