HISTONES AND BASIC POLYAMINO ACIDS STIMULATE UPTAKE OF ALBUMIN BY TUMOR CELLS IN CULTURE
HISTONES AND BASIC POLYAMINO ACIDS STIMULATE UPTAKE OF ALBUMIN BY TUMOR CELLS IN CULTURE
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DOI：
10.1126/science.150.3695.501
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发表时间：
1965-01-01
期刊：
影响因子：
56.9
通讯作者：
HANCOCK, R
中科院分区：
文献类型：
--
作者：
RYSER, HJP;HANCOCK, R
哺乳动物细胞摄取碱性蛋白质和聚氨基酸的速度比血清白蛋白高 3000 倍。当与血清白蛋白一起服用时，它们会增加白蛋白的摄取，其增加量与它们自身的摄取率相关，可以达到 50 倍以上。检测到的最低活性阈值（10-10 [图像]）与最有效的膜活性剂的活性相当。
Basic proteins and polyamino acids are taken up by mammalian cells at rates up to 3000 times greater than serum albumin. When given together with serum albumin they increase the albumin uptake by a factor that correlates with their own rate of uptake and can reach more than 50-fold. The lowest threshold of activity detected (10-10 [image]) is comparable to the activities of the most potent membrane-active agents.