CONDITIONAL ANALGESIA, DEFENSIVE FREEZING, AND BENZODIAZEPINES
CONDITIONAL ANALGESIA, DEFENSIVE FREEZING, AND BENZODIAZEPINES
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DOI：
10.1037/0735-7044.102.2.233
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发表时间：
1988-04-01
影响因子：
1.9
通讯作者：
HELMSTETTER, FJ
中科院分区：
文献类型：
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作者：
FANSELOW, MS;HELMSTETTER, FJ
当大鼠被置于一种通过巴甫洛夫条件反射过程与足电击相关的情况下时，它们会产生冻结的物种特异性防御反应，并降低对疼痛刺激的敏感性。在本实验中，三个苯二氮卓类对这两种反应的影响进行了检查。用福尔马林试验测定疼痛敏感性。同时观察福尔马林诱导的恢复性行为和冻结记录，而动物在休克相关的背景刺激的存在。结果发现，咪达唑仑（实验1和2），利（实验3），和地西泮（实验4）能够显着减弱条件性镇痛。米唑仑和地西泮也减少了冻结反应。这些抗焦虑药物减弱了这两种条件反应，这一发现表明，冻结和镇痛是由一个共同的恐惧样过程介导的。
When rats are placed in a situation that has come to be associated with footshock through the process of Pavlovian conditioning, they react with the species-specific defensive response of freezing and a reduction in sensitivity to painful stimulation. In the present experiments, the effects of three benzodiazepines on both of these responses were examined. Pain sensitivity was measured with the formalin test. Concurrent observations of formalian-induced recuperative behavior and freezing were recorded while the animals were in the presence of shock-associated contextual stimuli. It was found that midazolam (Experiment 1 and 2), chlordiazepoxide (Experiment 3), and diazepam (Experiment 4) were capable of significantly attenuating the conditional analgesia. Midzolam and diazepam also reduced the freezing response. The finding that these anxiolytic agents attenuated both conditional responses suggests that the freezing and analgesia are mediated by a common fearlike process.