Gender differences in depression: Findings from the STAR*D study
Gender differences in depression: Findings from the STAR*D study
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DOI：
10.1016/j.jad.2004.09.008
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发表时间：
2005-08-01
影响因子：
6.6
通讯作者：
Rush, AJ
中科院分区：
文献类型：
--
作者：
Marcus, SM;Young, EA;Rush, AJ
背景：流行病学研究一致报告了重度抑郁症（MDD）发病率和病程的性别差异。STAR*D（缓解抑郁的顺序治疗方案）多中心试验提供了一个独特的机会来探索非精神病性重度抑郁症门诊患者的性别差异。方法：本研究纳入STAR*D的前1500例MDD门诊患者。近三分之二的样本（62.8%）是女性。基线社会人口学因素、合并症和疾病特征按性别进行分析。结果：女性（占样本的62.8%）首次重度抑郁发作的发病年龄较年轻。他们通常报告的并发症状与焦虑症、躯体形式障碍、暴食症以及非典型症状一致。酗酒和吸毒在男性中更为常见。局限性：本报告是整个STAR*D样本的一个亚群。这些探索性分析旨在为进一步的假设检验确定潜在的性别差异。结论：在本研究人群中，MDD的性别特异性发病率与社区样本中发现的比例成正比，女性与男性的MDD患病率为1.7:1，这表明女性寻求治疗的人数有所增加。(c) 2004年Elsevier B.V.出版
Background: Epidemiologic research consistently reports gender differences in the rates and course of major depressive disorder (MDD). The STAR*D (Sequenced Treatment Alternatives to Relieve Depression) multicenter trial provides a unique opportunity to explore gender differences in outpatients with nonpsychotic MDD.Methods: This sample included the first 1500 outpatients with MDD who enrolled in STAR*D. Nearly two-thirds of the sample (62.8%) were women. Baseline sociodemographic factors, comorbidities, and illness characteristics were analyzed by gender.Results: Women (62.8% of the sample) had a younger age at onset of the first major depressive episode. They commonly reported concurrent symptoms consistent with anxiety disorders, somatoform disorder, and bulimia as well as atypical symptoms. Alcohol and drug abuses were more common in men.Limitations: This report is a subpopulation of the entire STAR*D sample. These exploratory analyses aimed to identify potential gender differences for further hypothesis testing.Conclusions: The gender-specific rate of MDD in this study population is proportional to rates found in community samples with a 1.7:1 prevalence of MDD in women vs. men which argues against increased treatment seeking in women. (c) 2004 Published by Elsevier B.V.