Response to creatine kinase and pressor response to orthostatic tolerance.
Response to creatine kinase and pressor response to orthostatic tolerance.
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对肌酸激酶的反应和对直立耐受的升压反应。
DOI：
10.1161/hypertensionaha.111.00713
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Fu,Qi
中科院分区：
文献类型：
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作者：
Okada,Yoshiyuki;Galbreath,MMelyn;Jarvis,SaraS;Bivens,TiffanyB;Vongpatanasin,Wanpen;Levine,BenjaminD;Fu,Qi
在最近的一篇出版物中，Okada等人1报告称，老年黑人的交感神经反应迟钝，但对直立性的加压反应比老年白人更大。作者得出结论，老年黑人在倾斜过程中对总肌肉交感神经活动的给定变化有更大的总外周阻力反应。作者认为，增强的交感血管传导或增强的非肾上腺素能血管收缩机制参与了这种增强的升压反应。[1]在之前的一篇文章中，还发现黑人女性的立位耐力更高。[2]在评论他们的建议时，我们提供了一个可能的机制贡献：我们提出黑人个体由于肌酸激酶（CK）活性高而具有更高的血管收缩力。3，4 CK迅速提供ATP用于高能量需求的细胞反应，并可增加ATP缓冲能力，导致增强的血管收缩性。3，4在需要高能量的亚细胞位置，CK迅速再生ATP，靠近膜上的Na+/K+-ATP酶和Ca 2 +-ATP酶，以及靠近收缩蛋白上的肌球蛋白轻链激酶和肌球蛋白ATP酶。4血管平滑肌收缩力的微小增加也会对血流阻力产生深远的影响，从而对动脉压产生深远的影响，如Poiffille-Hagen公式所示，体内的血流和阻力明显受到血管口径微小变化的影响。三，五
In a recent publication, Okada et al1 reported that elderly blacks have a blunted sympathetic neural responsiveness, but greater pressor response to orthostasis than elderly whites. The authors conclude that elderly blacks had a greater response in total peripheral resistance for a given change in total muscle sympathetic nerve activity during tilting. The authors suggested that an augmented sympathetic vascular transduction or enhanced nonadrenergic vasoconstrictor mechanisms are involved in this enhanced pressor response. 1 In an earlier article, greater orthostatic tolerance was also found in black women. 2 Commenting on their suggestions, we offer a possible mechanistic contribution.We have proposed that black individuals have higher vascular contractility because of high creatine kinase (CK) activity. 3, 4 CK rapidly provides ATP for highly energy-demanding cellular responses and may increase ATP-buffering capacity leading to enhanced vascular contractility. 3, 4 At subcellular locations with high energy demands, CK rapidly regenerates ATP, near Na+/K+–ATPase and Ca2+–ATPase at membranes, as well as near myosin light chain kinase and myosin ATPase at the contractile proteins. 4 Even a small increase in the contractility of vascular smooth muscle could have a profound effect on resistance of flow and hence arterial pressure, as expressed in the Poiseuille–Hagen formula, blood flow and resistance in vivo are markedly affected by small changes in the caliber of the vessel. 3, 5