Expression of urokinase plasminogen activator and receptor in conjunction with the ets family and AP-1 complex transcription factors in high grade prostate cancers
Expression of urokinase plasminogen activator and receptor in conjunction with the ets family and AP-1 complex transcription factors in high grade prostate cancers
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DOI：
10.1016/s0959-8049(01)00077-6
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发表时间：
2001-05-01
影响因子：
8.4
通讯作者：
Folk, WR
中科院分区：
文献类型：
--
作者：
Gavrilov, D;Kenzior, O;Folk, WR
尿激酶纤溶酶原激活物（uPA）及其受体（uPAR）的表达与肿瘤细胞的侵袭性相关，有助于确定前列腺癌和其他癌症的预后。本研究的目的是在前列腺癌中建立可能激活uPA增强子的诱导型AP-1和AP-1/PEA 3元件的ets家族和AP-1复合转录因子。uPA和uPAR在腺癌细胞中优先表达。而不是高级别前列腺癌的间质。ets家族旁系同源物Fli-1和Elf-1也在大多数癌症的腺癌细胞中高度表达，而Erg 1，2和Ets-2在少数癌症和Elk-l中表达。PEA 3和PU。1例表达最少。少数癌症表达高水平的细胞质和/或核c-Jun和c-Fos转录因子，我们推测这种表达的分子基础。(C)2001爱思唯尔科技有限公司版权所有。
Expression of the urokinase plasminogen activator (uPA) and its receptor (uPAR) correlates with tumour cell invasiveness and helps to determine the prognosis of prostate and other cancers. The purpose of this study was to establish in prostate cancer, the ets family and AP-1 complex transcription Factors that might activate the inducible AP-1 and AP-1/PEA3 elements of the uPA enhancer. uPA and uPAR were expressed preferentially in adenocarcinoma cells. but not the stroma of high grade prostate cancers. The ets family paralogues Fli-1 and Elf-1 were also highly expressed in adenocarcinoma cells of the majority of cancers, while Erg 1,2 and Ets-2 were expressed in a minority of cancers and Elk-l. PEA3 and PU. 1 were minimally expressed. A minority of cancers expressed high levels of cytoplasmic and/or nuclear c-Jun and c-Fos transcription factors, We speculate as to the molecular basis for such expression. (C) 2001 Elsevier Science Ltd. All rights reserved.