Identification of potential interaction networks using sequence-based searches for conserved protein-protein interactions or "interologs"
Identification of potential interaction networks using sequence-based searches for conserved protein-protein interactions or "interologs"
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DOI：
10.1101/gr.205301
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发表时间：
2001-12-01
期刊：
影响因子：
7
通讯作者：
Vidal, M
中科院分区：
文献类型：
--
作者：
Matthews, LR;Vaglio, P;Vidal, M
蛋白质相互作用图提供了对基因组序列可用的模型生物预测蛋白质之间的关系的见解。这些地图在产生潜在的相互作用网络方面很有用，这些网络证实了已知的复合物和途径的存在，并提出了以前未连接的途径之间存在新的复合物和 /或串扰的存在。但是，这种地图的产生是昂贵且劳动力密集的。在这里，我们研究了一种蛋白质相互作用图在一个物种中产生的蛋白质相互作用图在多大程度上可用于预测另一种物种中的相互作用。
Protein interaction maps have provided insight into the relationships among the predicted proteins of model organisms for which a genome sequence is available. These maps have been useful in generating potential interaction networks, which have confirmed the existence of known complexes and pathways and have suggested the existence of new complexes and or crosstalk between previously unlinked pathways. However, the generation of such maps is costly and labor intensive. Here, we investigate the extent to which a protein interaction map generated in one species can be used to predict interactions in another species.