Antigen-induced arthritis in rabbits: a comparative study between high-resolution ultrasound and contrast-enhanced ultrasound and pathologic findings
Antigen-induced arthritis in rabbits: a comparative study between high-resolution ultrasound and contrast-enhanced ultrasound and pathologic findings
复制标题
兔抗原性关节炎：高分辨率超声与超声造影及病理结果的比较研究
DOI：
10.1007/s00296-011-1817-y
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发表时间：
2012
影响因子：
4
通讯作者：
Huan Xu
中科院分区：
文献类型：
--
作者：
L. Qiu;Yong Jiang;Yan Luo;Ling;Huan Xu
本研究的目的是探讨高分辨率超声和超声造影评价兔膝关节抗原诱导性关节炎（AIA）滑膜炎的可行性和价值。将36只家兔随机分为3组，每组右膝关节内注射不同剂量的卵清蛋白（OVA）。第1、4周每组随机取6只动物处死。每个膝关节均接受高分辨率超声测量关节囊厚度和超声造影测量滑膜厚度。将超声检查结果与病理检查结果进行比较。不同剂量的卵清蛋白造模成功率不同，病理性滑膜炎评分不同，超声测量的关节囊和滑膜厚度也不同。超声对滑膜炎的诊断准确率高。超声测量显示，第4周的囊厚度小于第1周，而第4周的滑膜厚度大于第1周。关节囊及滑膜厚度与病理性滑膜炎评分呈显著正相关（P< 0.05）。第4周的滑膜厚度与滑膜炎评分的相关性大于关节囊厚度，而不是第1周。注射不同剂量的卵清蛋白，造模成功率和滑膜炎严重程度不同。高分辨率超声和超声造影可用于判断AIA是否成功，并评估滑膜炎的严重程度。在慢性炎症期，超声造影效果较好。
The objective of this study was to explore the feasibility and value of high-resolution ultrasound and contrast-enhanced ultrasound in evaluation of synovitis in rabbit knee joint in antigen-induced arthritis (AIA). Thirty-six rabbits were divided into three groups, each injected with different doses of ovalbumin (OVA) into the right knee joint. On week 1 and 4, 6 randomly selected in each group were killed. Each knee joint undergone the high-resolution ultrasound to measure capsule thickness and contrast-enhanced ultrasound to measure synovium thickness. The results from the ultrasound examinations were compared with those of pathologic examinations. Different OVA doses resulted in different modeling success rate, different pathological synovitis score, and different capsule and synovium thickness measured by ultrasound. The diagnostic accuracy of synovitis by ultrasound was high. The ultrasound measurement revealed that the capsule thickness on week 4 was lessened than that on week 1, while the synovial thickness on week 4 was greater than that on week 1. Both the joint capsule and synovium thickness measured by ultrasound were significantly and positively correlated to the pathologic synovitis score (P< 0.05). The synovial thickness on week 4 is more correlated to the synovitis score than the capsule thickness, rather than that on week 1. Injection of OVA of different doses results in different modeling success rate and synovitis severity. The high-resolution ultrasound and contrast-enhanced ultrasound can be used to determine whether the AIA was made successfully and evaluate the synovitis severity. In chronic inflammatory phase, the contrast-enhanced ultrasound has better effect.
影响因子：
4.9
作者：
Okura T;Marutsuka K;Hamada H;Sekimoto T;Fukushima T;Asada Y;Kitamura K;Chosa E
通讯作者：
Chosa E
使用靶向活检标本表征早期类风湿性关节炎滑膜炎的组织病理学和基因表达谱。
DOI：
--
发表时间：
2005
期刊：
Arthritis Research and Therapy 7・4
影响因子：
--
作者：
Tsubaki T;Arita N;Kawakami T;Yamamoto S;Nose M. et al.
通讯作者：
Nose M. et al.