Vascular actions of 20-HETE.
Vascular actions of 20-HETE.
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DOI：
10.1016/j.prostaglandins.2015.03.002
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发表时间：
2015-07
影响因子：
2.9
通讯作者：
Zeldin DC
中科院分区：
文献类型：
--
作者：
Hoopes SL;Garcia V;Edin ML;Schwartzman ML;Zeldin DC
20-羟基二十碳四烯酸(20-HETE)是花生四烯酸的代谢产物，在血管系统中具有多种生物学效应。本文综述了20-HETE对血管反应性、激活和重塑的影响，以及它在血管炎症和血管生成中的作用。本文综述了20-HETE和肾素-血管紧张素系统如何相互作用促进高血压、血管收缩和血管功能障碍的信息。20-HETE可增强糖尿病、缺血/再灌注和脑血管氧化应激模型中的血管炎症和损伤。最近的研究也证实了20-HETE在正常和病理血管生成条件下的作用。本综述还将讨论20-HETE诱导这些血管作用的分子机制。建议进行更多潜在的研究，以解决目前血管系统中20-HETE知识的不足。
20-hydroxyeicosatetraenoic acid (20-HETE) is a metabolite of arachidonic acid that exhibits a myriad of biological effects in the vascular system. This review discusses the current knowledge related to the effects of 20-HETE on vascular reactivity, activation, and remodeling, as well as its role in vascular inflammation and angiogenesis. The information explaining how 20-HETE and the renin-angiotensin system interact to promote hypertension, vasoconstriction, and vascular dysfunction is summarized in this article. 20-HETE enhances vascular inflammation and injury in models of diabetes, ischemia/reperfusion, and cerebrovascular oxidative stress. Recent studies also established a role for 20-HETE in normal and pathological angiogenesis conditions. This review will also discuss the molecular mechanisms through which 20-HETE induces these vascular actions. Potential additional studies are suggested to address shortcomings in the current knowledge of 20-HETE in the vascular system.