Longitudinal relationship of severe periodontitis with cognitive decline in older Japanese
Longitudinal relationship of severe periodontitis with cognitive decline in older Japanese
复制标题
DOI：
10.1111/jre.12348
复制
发表时间：
2016-10-01
影响因子：
3.5
通讯作者：
Matsubayashi, K.
中科院分区：
文献类型：
--
作者：
Iwasaki, M.;Yoshihara, A.;Matsubayashi, K.
背景和目的：研究牙周炎和认知状态之间纵向关系的流行病学数据非常有限，特别是在亚洲人群中。本研究调查了85名日本社区居民牙周炎与认知能力下降的纵向关系（平均年龄：79.3岁），数据来自2010年和2013年进行的全面健康检查。材料和方法：根据基线全口牙周检查，严重牙周炎的定义采用疾病控制和预防中心/美国牙周病学会的定义。在3年的研究期间，认知能力下降的定义是使用简易精神状态检查（MMSE）的结果。年龄，性别，教育，抑郁症，体重指数，吸烟状况，饮酒，运动，高血压，糖尿病，心血管疾病和中风的历史，和基线MMSE评分的信息被获得和测试作为潜在的混杂因素在statistical models.Results：在85名研究参与者中，21（24.7%）被定义为有严重的牙周炎。多变量Poisson回归分析显示，重度牙周炎与认知能力下降的风险增加显著相关[校正相对风险= 2.2; 95%可信区间（95%CI）：1.1-4.5]。此外，多变量线性回归分析显示，严重牙周炎的参与者有1.8点更大的下降（95%CI：-3.3 ~-0.2）。在样本量小的限制范围内，本研究的结果表明，严重的牙周炎与社区中认知功能的未来下降显著相关，居住在日本的老人
Background and Objective: Epidemiologic data examining the longitudinal relationship between periodontitis and cognitive status are very limited, especially in Asian populations. The present study examined the longitudinal relationship of periodontitis with cognitive decline in 85 Japanese community-dwelling individuals (average age: 79.3 years) for whom data were available from comprehensive health examinations conducted in 2010 and 2013.Material and Methods: Based on a baseline full-mouth periodontal examination, severe periodontitis was defined using a Centers for Disease Control and Prevention/American Academy of Periodontology definition. Cognitive decline during the 3-year study period was defined using the results of the Mini-Mental State Examination (MMSE). Information on age, gender, education, depression, body mass index, smoking status, alcohol use, exercise, hypertension, diabetes, history of cardiovascular disease and stroke, and baseline MMSE scores were obtained and tested as potential confounders in the statistical models.Results: Among 85 study participants, 21 (24.7%) were defined as having severe periodontitis. Multivariable Poisson regression analyses revealed that severe periodontitis was significantly associated with an increased risk of cognitive decline [adjusted relative risk = 2.2; 95% confidence interval (95% CI): 1.1-4.5]. Furthermore, multivariable linear regression analyses revealed that participants with severe periodontitis had a 1.8-point greater decrease (95% CI: -3.3 to -0.2) in MMSE score than those without severe periodontitis.Conclusion: Within the limitations related to its small sample size, the findings of the present study suggest that severe periodontitis is significantly associated with future decline in cognitive function among community-dwelling older Japanese subjects.