EVIDENCE FOR THE PRESENCE OF RECEPTORS FOR C-3 AND IGG FC ON HUMAN SYNOVIAL-CELLS
EVIDENCE FOR THE PRESENCE OF RECEPTORS FOR C-3 AND IGG FC ON HUMAN SYNOVIAL-CELLS
复制标题
DOI：
10.1002/art.1780230102
复制
发表时间：
1980-01-01
影响因子：
--
通讯作者：
VAUGHAN, JH
中科院分区：
文献类型：
--
作者：
THEOFILOPOULOS, AN;CARSON, DA;VAUGHAN, JH
评估了正常和类风湿滑膜组织的原代培养物和低温切片上 Ig[免疫球蛋白]G Fc 受体和 C3 [补体成分 3] 片段的存在。在此类培养物中发现的具有小行星投影的大圆形细胞中，相当大比例具有 IgG Fc 和 C3 片段的受体。固定了 C 但没有固定 EAC [红细胞抗体-C] 的革兰氏阴性细菌，以线性方式结合在滑膜低温切片的表层上。根据形态学和组织化学标准，初步确定携带这些受体的培养细胞代表滑膜衬里细胞的子集。讨论了滑膜衬里细胞上的此类受体在类风湿性关节炎发病机制中的可能作用。
The presence of receptors for Ig[immunoglobulin]G Fc and fragments of C3 [complement component 3] on primary cultures and cryostat sections of normal and rheumatoid synovial tissues was assessed. Significant proportions of large rounded cells with asteroid projections found in such cultures had receptors for IgG Fc and fragments of C3. Gram negative bacteria that had fixed C, but not EAC [erythrocyte-antibody-C], bound in a linear fashion on the superficial layers of synovial cryostat sections. On the basis of morphologic and histochemical criteria, cultured cells bearing these receptors were tentatively determined to represent a subset of synovial lining cells. The possible role of such receptors on synovial lining cells in the pathogenesis of rheumatoid arthritis was discussed.