Diabetes mellitus: channeling care through cellular discovery.
Diabetes mellitus: channeling care through cellular discovery.
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糖尿病：通过细胞发现引导护理。
DOI：
10.2174/156720210790820217
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发表时间：
2010-02
影响因子：
2.1
通讯作者：
Hou J
中科院分区：
文献类型：
--
作者：
Maiese K;Shang YC;Chong ZZ;Hou J
糖尿病（DM）影响世界人口的很大一部分，并且对这种疾病的护理对任何特定国家的国内生产总值都造成经济负担。此外，1型和2型糖尿病都变得越来越普遍，并且年轻人中葡萄糖耐量受损的发病率增加。DM的并发症是多变的，并且可以涉及全身的多个系统，这些系统容易受到氧化应激和凋亡细胞损伤的不利影响。由于这些原因，创新的策略是必要的实施新的治疗方法，通过进一步了解细胞途径，管理DM的病理后果产生的DM。特别是，辅酶β-烟酰胺腺嘌呤二核苷酸（NAD+）的前体烟酰胺和生长因子促红细胞生成素都为涉及细胞代谢稳态和炎症细胞控制的药物发现提供了新的平台。有趣的是，这些药物及其紧密相关的途径，包括细胞周期调控、蛋白激酶B、叉头转录因子和Wnt信号传导，也在更广泛的意义上作为疾病发作和进展的生物标志物发挥作用。
Diabetes mellitus (DM) impacts a significant portion of the world’s population and care for this disorder places an economic burden on the gross domestic product for any particular country. Furthermore, both Type 1 and Type 2 DM are becoming increasingly prevalent and there is increased incidence of impaired glucose tolerance in the young. The complications of DM are protean and can involve multiple systems throughout the body that are susceptible to the detrimental effects of oxidative stress and apoptotic cell injury. For these reasons, innovative strategies are necessary for the implementation of new treatments for DM that are generated through the further understanding of cellular pathways that govern the pathological consequences of DM. In particular, both the precursor for the coenzyme β-nicotinamide adenine dinucleotide (NAD+), nicotinamide, and the growth factor erythropoietin offer novel platforms for drug discovery that involve cellular metabolic homeostasis and inflammatory cell control. Interestingly, these agents and their tightly associated pathways that consist of cell cycle regulation, protein kinase B, forkhead transcription factors, and Wnt signaling also function in a broader sense as biomarkers for disease onset and progression.
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影响因子：
7.4
作者：
Bethea CL;Reddy AP;Tokuyama Y;Henderson JA;Lima FB
通讯作者：
Lima FB
影响因子：
5.3
作者：
Bakker, Walbert J.;van Dijk, Thamar B.;von Lindern, Marieke
通讯作者：
von Lindern, Marieke
影响因子：
4
作者：
Bakshi, Pancham;Margenthaler, Elaina;Mullan, Michael
通讯作者：
Mullan, Michael
影响因子：
4.8
作者：
Balan, Vitaly;Miller, Gregory S.;Tzivion, Guri
通讯作者：
Tzivion, Guri
DOI：
10.1093/gerona/60.4.471
发表时间：
2005-04-01
影响因子：
5.1
作者：
Beeri, MS;Silverman, JM;Haroutunian, V
通讯作者：
Haroutunian, V