Second-Generation Trabecular Micro-Bypass Stents as Standalone Treatment for Glaucoma: A 36-Month Prospective Study
Second-Generation Trabecular Micro-Bypass Stents as Standalone Treatment for Glaucoma: A 36-Month Prospective Study
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DOI：
10.1007/s12325-019-00984-9
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发表时间：
2019-07-01
影响因子：
3.8
通讯作者：
Conrad-Hengerer, Ina
中科院分区：
文献类型：
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作者：
Hengerer, Fritz H.;Auffarth, Gerd U.;Conrad-Hengerer, Ina
引言评价两种第二代小梁微旁路支架（iStent inject（（R）），Glaukos Corp.，圣克莱门特，加利福尼亚州，美国）的眼睛，主要是原发性开角型青光眼（POAG）和相当大的术前疾病burner.MethodsEyes与POAG，假性剥脱性青光眼（PXG），并置性窄角型青光眼（NAG，与开角型配置在该地区的植入），或继发性青光眼被列入这一前瞻性，非随机，连续病例系列。所有患眼均接受了iStent内注射植入术作为唯一手术。通过36个月的评估包括IOP，药物治疗，矫正远视力（CDVA），继发性青光眼手术，并发症和不良事件。ResultsTwo iStent注射支架植入44眼连续（POAG=38，PXG=4，appositional NAG=1，继发性新生血管性青光眼=1）的31例患者，33只眼睛有36个月的随访数据。术前平均IOP为25.36.0mmHg，平均用药2.98 ± 0.88次，75%的患眼用药3-5次，无患眼未用药，50%的患眼有既往青光眼手术史。术后36个月，平均IOP降低42%至14.6 +/-2.0 mmHg（与术前相比，p= 20%）。此外，97%的眼睛达到IOP
IntroductionTo evaluate long-term outcomes following stand-alone implantation of two second-generation trabecular micro-bypass stents (iStent inject((R)), Glaukos Corp., San Clemente, CA, USA) in eyes with predominantly primary open-angle glaucoma (POAG) and considerable preoperative disease burden.MethodsEyes with POAG, pseudoexfoliative glaucoma (PXG), appositional narrow-angle glaucoma (NAG, with open-angle configuration in the area of implantation), or secondary glaucoma were included in this prospective, non-randomized, consecutive case series. All eyes underwent ab interno iStent inject implantation as a sole procedure. Assessments through 36months included IOP, medications, corrected distance visual acuity (CDVA), secondary glaucoma surgeries, and complications and adverse events.ResultsTwo iStent inject stents were implanted in 44 consecutive eyes (POAG=38, PXG=4, appositional NAG=1, secondary neovascular glaucoma=1) of 31 patients, and 33 eyes had 36-month follow-up data. Preoperative mean IOP was 25.36.0mmHg on a mean of 2.980.88 medications, with 75% of eyes on 3-5 medications, no eyes medication-free, and 50% of eyes with history of prior glaucoma surgery. At 36months postoperatively, mean IOP reduced by 42% to 14.6 +/- 2.0mmHg (p= 20% versus preoperatively. In addition, 97% of eyes reached IOP