Recovery pattern of non-protein respiratory quotient and non-esterified fatty acids after liver resection
Recovery pattern of non-protein respiratory quotient and non-esterified fatty acids after liver resection
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肝切除术后非蛋白质呼吸商和非酯化脂肪酸的恢复模式
DOI：
10.1016/j.nut.2013.09.012
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发表时间：
2014
期刊：
影响因子：
4.4
通讯作者：
Takeda E
中科院分区：
文献类型：
--
作者：
Sugihara K;Yamanaka-Okumura H;Teramoto A;Urano E;Katayama T;Mori H;Utsunomiya T;Shimada M;Takeda E
围手术期营养护理是维持术前、术后营养状况的重要环节。然而，很少有报道探讨肝切除术后的能量代谢。本研究的目的是确定肝细胞癌（HCC）和健康的活体供者肝transplant.Methods18例肝癌组和13例活体供者肝移植（供者组）肝切除术前后的能量代谢，血液生化和营养状况的差异。供体组按年龄分为Y型供体组（年龄< 40岁，n = 7）和O型供体组（年龄≥ 40岁，n = 6）。能量代谢测定在术前一天和术后第7天（POD）和第14天，血液生化也examined.ResultsRecovery的非蛋白呼吸商（npRQ）和血液生化数据，如总胆红素，天冬氨酸氨基转移酶和丙氨酸氨基转移酶水平，观察Y-供体组在POD 14。然而，尽管HCC和O-供体组的生化数据有所改善，但npRQ在POD 14时保持不变。结论HCC患者和老年供体的npRQ改善时间长于血液生化数据。由于npRQ的恢复与供体年龄有关，因此可能需要更长时间的仔细营养管理，这取决于肝切除术后每位患者的病理生理状况。
ObjectivePerioperative nutritional care is important to maintain preoperative and postoperative nutritional status. However, few reports have investigated energy metabolism after hepatectomy. The aim of this study was to determine differences in energy metabolism, blood biochemistry, and nutritional status before and after liver resection in patients with hepatocellular carcinoma (HCC) and healthy living donors for liver transplantation.MethodsEighteen hospitalized patients with HCC group and 13 living donors for liver transplantation (donor group) were enrolled in this study. The donor group was divided into two groups on the basis of age; Y-donor group (age < 40 y, n = 7), and O-donor group (age ≥ 40 y, n = 6). Energy metabolism was measured by indirect calorimetry at preoperative day and postoperative day (POD) 7 and 14, and blood biochemistry was also examined.ResultsRecovery of non-protein respiratory quotient (npRQ) and blood biochemical data such as total bilirubin, aspartate aminotransferase and alanine aminotransferase levels were observed in Y-donor group on POD 14. However, although biochemical data improved in the HCC and O-donor group, npRQ remained unchanged on POD 14.ConclusionsImprovement of npRQ took longer than blood biochemical data in patients with HCC and older donors. Because the recovery of npRQ is associated with donor age, careful nutritional management may be required for a longer time depending on the pathophysiological condition of each patient after hepatectomy.