Immunohistochemical identification and localization of pancreatic polypeptide cells in the pancreas and gastrointestinal tract of the human fetus and adult man
Immunohistochemical identification and localization of pancreatic polypeptide cells in the pancreas and gastrointestinal tract of the human fetus and adult man
复制标题
人类胎儿和成年男子胰腺和胃肠道中胰多肽细胞的免疫组织化学鉴定和定位
作者：
Dr C. Paulin;P. Dubois
摘要 使用抗牛 PP (BPP) 血清检测人类胎儿、早产儿的胰腺和胃肠道以及从正常胃十二指肠内镜检查患者活检获得的成年男性的胰腺、胃窦和空肠中含有胰多肽 (PP) 的细胞。通过研究 PP 细胞的分布与胰高血糖素、生长抑素和胰岛素细胞的分布的比较来确定定位。第一个 PP 细胞在妊娠 10 周时出现在胰腺中。它们优先位于胰头的下部。通过牛胰多肽、胰高血糖素和胰岛素对反应的抑制作用来确定免疫细胞学反应的特异性，不会改变免疫细胞学反应。
SummaryPancreatic polypeptide (PP)-containing cells were detected by using anti-bovine PP (BPP) serum in the pancreas and gastrointestinal tract of human fetuses, premature infants and in the pancreas, antrum and jejunum of adult man obtained by biopsy from patients with normal gastroduodenal endoscopy. The localization was established by studying the distribution of PP cells in comparison to the distribution of glucagon-, somatostatin- and insulin cells. The first PP cells are seen in the pancreas at 10 weeks of gestation. They are located preferentially in the lower part of the head of the pancreas. The specificity of immunocytological reaction was ascertained by the inhibition of the reaction by bovine pancreatic polypeptide, glucagon and insulin did not modify the immunocytological reaction.