Expression and prognostic role of cyclin-dependent kinase 1 (cdc2) in hepatocellular carcinoma
Expression and prognostic role of cyclin-dependent kinase 1 (cdc2) in hepatocellular carcinoma
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DOI：
10.1159/000012140
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发表时间：
2000-01-01
期刊：
影响因子：
3.5
通讯作者：
Matsuura, N
中科院分区：
文献类型：
--
作者：
Ito, Y;Takeda, T;Matsuura, N
对 101 例肝细胞癌 (HCC) 中细胞周期蛋白依赖性激酶 1 (cdc2)、细胞周期蛋白 A 和细胞周期蛋白 B1 的表达进行了免疫组织化学研究。 cdc2过表达与晚期、门静脉侵犯、肝内转移、分化差、甲胎蛋白水平高、体积大、Ki-67标记指数高和预后不良直接相关。 Cyclin A 和 B1 过表达表现出与 cdc2 相似的趋势，但多变量分析并未将它们视为独立的预后因素。这些研究结果表明，cdc2 在 HCC 细胞周期进展和细胞增殖中发挥 G2/M 调节剂的最关键作用，并显着预测该癌症的复发，版权所有 (C) 2000 S. Karger AG，巴塞尔。
The expression of cyclin-dependent kinase 1 (cdc2), cyclin A and cyclin B1 was immunohistochemically studied in 101 hepatocellular carcinomas (HCC). cdc2 overexpression was directly related to advanced stage, portal invasion, intrahepatic metastasis, poor differentiation, high a-fetoprotein level, large size, high Ki-67 labeling index and poor prognosis. Cyclin A and B1 overexpression showed similar tendency to that of cdc2, but they were not recognized as independent prognostic factors by multivariate analysis, These findings suggest that cdc2 plays the most crucial role of the G2/M modulators in cell cycle progression and cell proliferation of HCC and significantly predicts the recurrence of th is carcinoma, Copyright (C) 2000 S. Karger AG, Basel.