IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma
IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma
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DOI：
10.1016/j.bbrc.2006.05.080
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发表时间：
2006-07-21
影响因子：
3.1
通讯作者：
Lee, Hyo-Suk
中科院分区：
文献类型：
--
作者：
Kim, Yoon Jun;Yoon, Jung-Hwan;Lee, Hyo-Suk
本研究的目的是确定 IGF2 多态性是否与乙型肝炎病毒 (HBV) 感染的清除和肝细胞癌 (HCC) 的风险相关。总共 1095 名韩国受试者前瞻性地参加了这项病例对照研究。测定各组的IGF2多态性率。 IGF2 + 820E 等位基因 (IGF2 + 820G/G) 和 IGF2 + 6815A/A 基因型与 HBV 感染的消退密切相关（分别为 OR = 0.62-0.73；P = 0.001-0.03 和 OR = 0.71；P = 0.03）。单倍型分析显示IGF2-单倍型5（A-C-C-T-A-T-G）和IM-单倍型1（T-C-T-T-A-C-A）与HBV感染的清除和持续存在显着相关（OR = 0.55-0.58，P = 0.009-0.01和OR = 1.31-1.65，P =分别为 0.001-0.007）。另一方面，IGF2 + 2482C/C 或 +820G/G 基因型与较高的 HCC 风险显着相关（OR = 1.88、1.68；P = 0.04）。研究发现，IGF2 多态性与慢性 HBV 感染患者的 HBV 清除或 HCC 发生密切相关。 (c) 2006 Elsevier Inc. 保留所有权利。
The aim of this study was to determine whether IGF2 polymorphisms are associated with the clearance of hepatitis B virus (HBV) infection and the risk of hepatocellular carcinoma (HCC). A total of 1095 Korean subjects were prospectively enrolled in this case-control study. The rates of IGF2 polymorphisms were determined in each group. The IGF2 + 820E allele (IGF2 + 820G/G) and the IGF2 + 6815A/A genotype were strongly associated with the resolution of HBV infection (OR = 0.62-0.73; P = 0.001-0.03 and OR = 0.71; P = 0.03, respectively). Haplotype analysis showed that IGF2-haplotype5 (A-C-C-T-A-T-G) and IM-haplotypel (T-C-T-T-A-C-A) were significantly associated with the clearance and persistence of HBV infection (OR = 0.55-0.58, P = 0.009-0.01 and OR = 1.31-1.65, P = 0.001-0.007, respectively). On the other hand, the IGF2 + 2482C/C or +820G/G genotypes were significantly associated with a higher risk of HCC (OR = 1.88, 1.68; P = 0.04). IGF2 polymorphisms were found to be strongly associated with the clearance of HBV or the occurrence of HCC in patients with chronic HBV infection. (c) 2006 Elsevier Inc. All rights reserved.