The sorry state of F2 hybrids: Consequences of rapid mitochondrial DNA evolution in allopatric populations
The sorry state of F2 hybrids: Consequences of rapid mitochondrial DNA evolution in allopatric populations
复制标题
DOI：
10.1086/509046
复制
发表时间：
2006-12-01
影响因子：
2.9
通讯作者：
Harrison, J. S.
中科院分区：
文献类型：
--
作者：
Burton, R. S.;Ellison, C. K.;Harrison, J. S.
通过自然选择和遗传漂变的过程，异地种群发生遗传分化，最终可能成为生殖不相容的种群。在合子前生殖隔离的情况下，物种形成基因的候选系统逻辑上包括涉及配偶或配子识别的基因。然而，只有合子后隔离存在，候选物种形成基因可能包括任何影响杂交性能的基因。我们假设，因为线粒体基因经常比它们相互作用的核基因进化得更快，种群间杂交可能对线粒体功能特别具有破坏性。了解潜在的影响intergenomic（核和线粒体）coadaptation的异域种群的潮间带桡足类Tigriopus californicus的进化需要一个广泛的综合研究计划，在这里，我们提出了实验的结果，跨越光谱的生物组织，以证明分子进化的生理性能和有机体健身的后果。我们认为，线粒体功能的破坏，已知会导致一系列不同的人类疾病，可能经常导致动物种群间和种间杂种的适应性降低。
Through the processes of natural selection and genetic drift, allopatric populations diverge genetically and may ultimately become reproductively incompatible. in cases of prezygotic reproductive isolation, candidate systems for speciation genes logically include genes involved in mate or gamete recognition. However, where only postzygotic isolation exists, candidate speciation genes could include any genes that affect hybrid performance. We hypothesize that because mitochondrial genes frequently evolve more rapidly than the nuclear genes with which they interact, interpopulation hybridization might be particularly disruptive to mitochondrial function. Understanding the potential impact of intergenomic (nuclear and mitochondrial) coadaptation on the evolution of allopatric populations of the intertidal copepod Tigriopus californicus has required a broadly integrative research program; here we present the results of experiments spanning the spectrum of biological organization in order to demonstrate the consequences of molecular evolution on physiological performance and organismal fitness. We suggest that disruption of mitochondrial function, known to result in a diverse set of human diseases, may frequently underlie reduced fitness in interpopulation and interspecies hybrids in animals.