Quantification of Pharmaceutical Bitterness Using a Membrane Electrode Based on a Hydrophobic Tetrakis [3,5-Bis (trifluoromethyl) phenyl] Borate
Quantification of Pharmaceutical Bitterness Using a Membrane Electrode Based on a Hydrophobic Tetrakis [3,5-Bis (trifluoromethyl) phenyl] Borate
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DOI：
10.3390/chemosensors9020028
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发表时间：
2021-02-01
期刊：
影响因子：
4.2
通讯作者：
Toko, Kiyoshi
中科院分区：
文献类型：
--
作者：
Wu, Xiao;Shiino, Takeshi;Toko, Kiyoshi
量化苦味的技术对于药物分类至关重要。正如之前报道的，带有脂质聚合物膜的味觉传感器可以对药物中的苦味盐酸物质做出反应。然而，脂质磷酸二正癸酯（PADE）和增塑剂邻乙酰柠檬酸三丁酯（TDAB）之间的酸水解反应导致储存期间传感器响应恶化。考虑到商业化的运输和保存成本，需要在长期储存过程中保持物理和化学稳定性的膜组件。在这里，我们提出了一种基于疏水性四[3,5-双（三氟甲基）苯基]硼酸盐（TFPB）和增塑剂2-硝基苯基辛基醚（NPOE）的膜电极，用于定量药物苦味；它们在加速劣化前后保持稳定的响应，以及高选择性和灵敏度。用完全解离物质代替非完全解离脂质尚属首次尝试。我们的工作解决了带有带负电荷的疏水膜的苦味传感器的长期稳定性问题。同时，我们提供了使用含有相反电荷杂质的酯增塑剂来选择膜表面表面电荷改性剂的机会。
Technologies for quantifying bitterness are essential for classifying medicines. As previously reported, taste sensors with lipid polymer membranes can respond to bitter hydrochloride substances in pharmaceuticals. However, the acid hydrolysis reaction between the lipid phosphoric acid di-n-decyl ester (PADE) and the plasticizer tributyl o-acetylcitrate (TDAB) led to a deterioration in sensor responses during storage. Given the cost of transportation and preservation for commercialization, membrane components that maintain physical and chemical stability during long-term storage are needed. Here we present a membrane electrode based on hydrophobic tetrakis [3,5-bis (trifluoromethyl) phenyl] borate (TFPB) and a plasticizer 2-nitrophenyl octyl ether (NPOE) for the quantification of pharmaceutical bitterness; they maintain a stable response before and after accelerated deterioration, as well as high selectivity and sensitivity. It is a first attempt to use a completely dissociative substance to replace non-completely dissociative lipids. Our work offsets the long-term stability issue of a bitterness sensor with a negatively charged hydrophobic membrane. Meanwhile, we provide the opportunity to select surface charge modifiers for a membrane surface using ester plasticizers containing oppositely charged impurities.