AGE-RELATED DIFFERENCES IN ABSOLUTE NUMBERS OF SKELETAL-MUSCLE SATELLITE CELLS
AGE-RELATED DIFFERENCES IN ABSOLUTE NUMBERS OF SKELETAL-MUSCLE SATELLITE CELLS
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DOI：
10.1002/mus.880060807
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发表时间：
1983-01-01
期刊：
影响因子：
3.4
通讯作者：
SCHULTZ, E
中科院分区：
文献类型：
--
作者：
GIBSON, MC;SCHULTZ, E
通过将肌纤维核（肌核和卫星细胞核）的光学显微镜和EM定量数据与用于确定总肌肉DNA含量的生化测定相关联，估计年轻和成年大鼠骨骼肌中卫星细胞（SC）的绝对数量。表达为总肌纤维核的比例和绝对数量，SC是更多的主要氧化比目鱼肌比在混合糖酵解/氧化趾长伸肌（EDL）肌肉在1，12和24个月。年龄。随着年龄的增长，两种肌肉中SC的比例逐渐下降，但比目鱼肌中的绝对数量在1至12个月之间显著增加，而EDL在每个检查的年龄段之间表现出SC的持续显着下降。
The absolute number of satellite cells (SC) in young and adult rat skeletal muscle was estimated by correlating data from light microscopic and EM quantitation of myofiber nuclei (myonuclei and satellite cell nuclei) with biochemical assays for determining total muscle DNA content. Expressed both as a proportion of total myofiber nuclei and as absolute numbers, SC are more numerous in the predominantly oxidative soleus muscle than in the mixed glycolytic/oxidative extensor digitorum longus (EDL) muscle at 1, 12 and 24 mo. of age. SC proportions decline gradually in both muscles with advancing age, but absolute numbers increase significantly in the soleus between 1 and 12 mo., while EDL exhibits a continuous significant decline in SC between each of the ages examined.