Fluorescent dye-doped silica nanoparticles: new tools for bioapplications
Fluorescent dye-doped silica nanoparticles: new tools for bioapplications
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DOI：
10.1039/c2cc16306c
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发表时间：
2012-01-01
影响因子：
4.9
通讯作者：
Hong, Jong-In
中科院分区：
文献类型：
--
作者：
Bae, Se Won;Tan, Weihong;Hong, Jong-In
破译各种生物事件的需要导致了一些疾病过程背后的分子机制的阐明。因此，检测和同时监测生物靶点之间的化学相互作用已成为医学诊断、靶向治疗和分子生物学中不可或缺的技术。纳米材料的多路应用，代表了纳米技术与生物学的融合，已经改变了生物分析的前景，并提供了各种有前途的工具。在这些纳米材料中，荧光染料掺杂二氧化硅纳米颗粒在高级生物分析中表现出了良好的潜力，有助于在分子水平上更深入地了解生物学和医学。特别是，二氧化硅纳米颗粒已应用于癌症和基因/药物传递的诊断和治疗应用。本文综述了荧光染料掺杂二氧化硅纳米颗粒的合成、生物相容性和生物应用方面的最新进展。
The need to decipher various biological events has led to the elucidation of the molecular mechanisms underlying a number of disease processes. Consequently, the detection and simultaneous monitoring of chemical interactions between biological targets has become indispensable in medical diagnosis, targeted therapeutics, and molecular biology. Multiplexed applications employing nanomaterials, which represent the integration of nanotechnology and biology, have changed the bioanalytical outlook and provided various promising tools. Among these nanomaterials, fluorescent dye-doped silica nanoparticles have demonstrated excellent potential for use in advanced bioanalysis to facilitate deeper understanding of biology and medicine at the molecular level. In particular, silica nanoparticles have been applied to diagnostics and therapeutic applications in cancer and gene/drug delivery. This feature article summarizes recent developments in the synthesis, biocompatibility, and bioapplications of fluorescent dye-doped silica nanoparticles.