Birthweight and risk of type 1 diabetes in children and young adults:: a population-based register study
Birthweight and risk of type 1 diabetes in children and young adults:: a population-based register study
复制标题
DOI：
10.1007/s00125-005-1759-6
复制
发表时间：
2005-06-01
期刊：
影响因子：
8.2
通讯作者：
Nyström, L
中科院分区：
文献类型：
--
作者：
Dahlquist, GG;Pundziute-Lyckå, A;Nyström, L
我们调查了1型糖尿病与发病时年龄的出生体重之间的关系。这项基于人群的病例参考研究使用了来自两个全国性病例登记处的数据，这些病例登记处与瑞典医学出生登记处相关联，涵盖了0至14岁（自1977年7月1日起）和15至34岁年龄组（自1983年1月1日起）的1型糖尿病事件病例。在与医疗出生登记有关的病例中，2003年1月1日之前记录的15岁以前发病的病例共有9 283例，30岁以前发病和1973年以后出生的病例有1 610例（占合格病例的95%）。多胞胎和糖尿病母亲的婴儿被排除在外。按孕周列出的性别特异性出生体重表示为标准差（SDS）的倍数，并根据出生年份、母亲年龄和产次进行调整。10岁以前发病的病例（n= 5，792）显示了校正出生体重SDS的比值比（OR）的显著线性趋势（SDS的OR：0.062; 95%CI：0.037-0.086; p < 0.0001），而10-29岁发病的病例未显示出显著趋势（SDS的OR：0.004; 95% CI：-0.007至0.0014; p=0.22）。1型糖尿病风险和出生体重之间的关联似乎仅限于年轻时发病的病例。
We investigated the association between type 1 diabetes and birthweight by age at disease onset. This population-based case-referent study used data from two nationwide case registers that are linked to the Swedish Medical Birth Registry and cover incident cases of type 1 diabetes in the 0- to 14-year (since 1 July 1977) and 15- to 34-year age groups (since 1 January 1983). Of the cases linked to the Medical Birth Registry, a total of 9,283 cases with onset before 15 years of age was recorded before 1 January 2003, and 1,610 cases were recorded with onset before 30 years of age and born after 1973 (together 95% of eligible cases). Multiple births and babies of diabetic mothers were excluded. Sex-specific birthweight by gestational week is expressed as multiples of the standard deviation (SDS) and adjusted for year of birth, maternal age and parity. Cases with onset before 10 years of age (n=5,792) showed a significant linear trend in odds ratio (OR) by SDS of adjusted birthweight (OR by SDS: 0.062; 95% CI: 0.037-0.086; p < 0.0001), while cases with onset at the age of 10-29 years showed no significant trend (OR by SDS: 0.004; 95% CI: -0.007 to 0.0014; p=0.22). The association between type 1 diabetes risk and birthweight seems to be limited to cases with disease onset in younger years.