Peroxisome Proliferator-Activator Receptor γ: A Link between Macrophage CD36 and Inflammation in Malaria Infection.
Peroxisome Proliferator-Activator Receptor γ: A Link between Macrophage CD36 and Inflammation in Malaria Infection.
复制标题
过氧化物酶体增殖物激活剂受体γ：巨噬细胞CD36 与疟疾感染炎症之间的联系。
DOI：
10.1155/2012/640769
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发表时间：
2012
期刊：
影响因子：
2.9
通讯作者：
Ren,Yi
中科院分区：
文献类型：
--
作者：
Ren,Yi
由恶性疟原虫引起的严重疟疾感染是一种威胁生命的全球疾病，也是全世界死亡的主要原因。 深入的研究表明，巨噬细胞在控制炎症和免疫反应以及清除恶性疟原虫寄生红细胞（PE）方面发挥着至关重要的作用。本文重点研究巨噬细胞 CD36 如何识别和内化 PE 并参与响应恶性疟原虫的炎症信号传导。此外，还强调了我们目前对 PPARγ 对 CD36 的生物作用和宿主清除疟疾的理解的最新进展。
Severe malaria infection caused byPlasmodium falciparumis a global life‐threatening disease and a leading cause of death worldwide. Intensive investigations have demonstrated that macrophages play crucial roles in control of inflammatory and immune responses and clearance ofPlasmodium-falciparum‐parasitized erythrocytes (PE). This paper focuses on how macrophage CD36 recognizes and internalizes PE and participates the inflammatory signaling in response toPlasmodium falciparum. In addition, recent advances in our current understanding of the biological actions of PPARγon CD36 and malaria clearance from the hosts are highlighted.