Kinetic control of multiple forms of Ca2+ spikes by inositol trisphosphate in pancreatic acinar cells
Kinetic control of multiple forms of Ca2+ spikes by inositol trisphosphate in pancreatic acinar cells
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DOI：
10.1083/jcb.146.2.405
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发表时间：
1999-07-26
影响因子：
7.8
通讯作者：
Kasai, H
中科院分区：
文献类型：
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作者：
Ito, K;Miyashita, Y;Kasai, H
在胰腺腺泡细胞中，使用笼化肌醇1,4,5-三磷酸（IP3）和低亲和力Ca2+指示剂ETC，研究了激动剂诱导Ca2+峰值的机制。笼化IP3的快速光解能够产生乙酰胆碱（ACh）诱导的三种形式的Ca2+峰值：局部Ca2+峰值和亚微摩尔(
The mechanisms of agonist-induced Ca2+ spikes have been investigated using a caged inositol 1,4,5-trisphosphate (IP3) and a low-affinity Ca2+ indicator, ETC, in pancreatic acinar cells. Rapid photolysis of caged IP3 was able to reproduce acetylcholine (ACh)-induced three forms of Ca2+ spikes: local Ca2+ spikes and submicromolar (