Thermal Ablative Therapies and Immune Checkpoint Modulation: Can Locoregional Approaches Effect a Systemic Response?
Thermal Ablative Therapies and Immune Checkpoint Modulation: Can Locoregional Approaches Effect a Systemic Response?
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DOI：
10.1155/2016/9251375
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发表时间：
2016
影响因子：
2
通讯作者：
Sheth RA
中科院分区：
文献类型：
--
作者：
Mehta A;Oklu R;Sheth RA
经皮图像引导消融是一种越来越常见的治疗多种实体器官恶性肿瘤。虽然历史上这些技术已被限制在小的，不可切除的肿瘤的管理，有一个不断扩大的赞赏这些局部干预可能导致的全身性影响。在这篇综述中，我们总结了最常见的热消融方式的作用机制，并强调了关于热消融和免疫系统之间相互作用的知识的关键进展。
Percutaneous image-guided ablation is an increasingly common treatment for a multitude of solid organ malignancies. While historically these techniques have been restricted to the management of small, unresectable tumors, there is an expanding appreciation for the systemic effects these locoregional interventions can cause. In this review, we summarize the mechanisms of action for the most common thermal ablation modalities and highlight the key advances in knowledge regarding the interactions between thermal ablation and the immune system.