Knowledge Mapping of Necroptosis From 2012 to 2021: A Bibliometric Analysis.
Knowledge Mapping of Necroptosis From 2012 to 2021: A Bibliometric Analysis.
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DOI：
10.3389/fimmu.2022.917155
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发表时间：
2022
影响因子：
7.3
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中科院分区：
文献类型：
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坏死性凋亡是最近发现的一种程序性细胞死亡，在病理学上与多种疾病有关，因此是治疗疾病的有希望的靶点。然而，目前缺乏关于整个坏死性凋亡研究现状的全面、客观的报告。因此，本研究旨在进行文献计量分析，以量化和识别近十年来坏死性凋亡研究的现状和趋势问题。文章取自 Web of Science 核心合集数据库。我们使用两种文献计量工具（CiteSpace 和 VOSviewer）通过分析年度出版物、期刊、共同被引期刊、国家/地区、机构、作者和共同被引作者来量化和识别个人影响和合作信息。随后，我们通过分析关键词和共引参考文献的共现和爆发，确定了坏死性凋亡的研究热点领域。 2012年至2021年，来自82个国家/地区的885个机构的19,687名作者在786种学术期刊上共发表了3,111篇有关坏死性凋亡的研究论文。大部分出版物来自中国和美国，其中美国在坏死性凋亡研究方面保持主导地位；其中，中国科学院和根特大学是最活跃的机构。 Peter Vandenabeele 发表的论文最多，而 Alexei Degterev 的同被引次数最多。 《细胞死亡与疾病》发表了有关坏死性凋亡的论文最多，而《细胞》是共同被引次数排名第一的期刊，这些出版物的主要领域是分子、生物学和免疫学。高频关键词主要包括分子相关（MLKL、TNF-α、NF-κB、RIPK3、RIPK1）、病理过程相关（细胞死亡、凋亡、坏死性凋亡、坏死、炎症）、疾病相关（癌症、缺血/再灌注损伤、感染、癌、阿尔茨海默病）。坏死性凋亡研究在过去十年中稳步稳步增长。目前坏死性凋亡的研究重点是其与其他类型细胞死亡的交叉、在疾病治疗中的潜在应用以及进一步的机制。其中，与铁死亡的协同作用、进一步的RIPK1/RIPK3/MLKL研究、其与炎症和氧化应激的关联及其转化应用，以及治疗癌症和神经退行性疾病的治疗潜力是趋势研究领域。这些可能为坏死性凋亡领域的进一步研究提供思路。
Necroptosis, a recently discovered programmed cell death, has been pathologically linked to various diseases and is thus a promising target for treating diseases. However, a comprehensive and objective report on the current status of entire necroptosis research is lacking. Therefore, this study aims to conduct a bibliometric analysis to quantify and identify the status quo and trending issues of necroptosis research in the last decade. Articles were acquired from the Web of Science Core Collection database. We used two bibliometric tools (CiteSpace and VOSviewer) to quantify and identify the individual impact and cooperation information by analyzing annual publications, journals, co-cited journals, countries/regions, institutions, authors, and co-cited authors. Afterwards, we identified the trending research areas of necroptosis by analyzing the co-occurrence and burst of keywords and co-cited references. From 2012 to 2021, a total of 3,111 research articles on necroptosis were published in 786 academic journals by 19,687 authors in 885 institutions from 82 countries/regions. The majority of publications were from China and the United States, of which the United States maintained the dominant position in necroptosis research; meanwhile, the Chinese Academy of Sciences and Ghent University were the most active institutions. Peter Vandenabeele published the most papers, while Alexei Degterev had the most co-citations. Cell Death & Disease published the most papers on necroptosis, while Cell was the top 1 co-cited journal, and the major area of these publications was molecular, biology, and immunology. High-frequency keywords mainly included those that are molecularly related (MLKL, TNF-alpha, NF-κB, RIPK3, RIPK1), pathological process related (cell-death, apoptosis, necroptosis, necrosis, inflammation), and disease related (cancer, ischemia/reperfusion injury, infection, carcinoma, Alzheimer’s disease). Necroptosis research had a stable stepwise growth in the past decade. Current necroptosis studies focused on its cross-talk with other types of cell death, potential applications in disease treatment, and further mechanisms. Among them, the synergy with ferroptosis, further RIPK1/RIPK3/MLKL studies, its association with inflammation and oxidative stress and translational applications, and the therapeutic potential to treat cancer and neurodegenerative diseases are the trending research area. These might provide ideas for further research in the necroptosis field.