Oligomeric nanoparticles functionalized with NIR-emitting CdTe/CdS QDs and folate for tumor-targeted imaging
Oligomeric nanoparticles functionalized with NIR-emitting CdTe/CdS QDs and folate for tumor-targeted imaging
复制标题
用近红外发射 CdTe/CdS QD 和叶酸功能化的寡聚纳米颗粒用于肿瘤靶向成像
DOI：
10.1016/j.biomaterials.2014.05.071
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发表时间：
2014
期刊：
影响因子：
14
通讯作者：
Liang Gaolin
中科院分区：
文献类型：
--
作者：
Yuan Yue;Zhang Jia;An Linna;Cao Qinjingwen;Deng Yun;Liang Gaolin
在此，我们报道了一种生物相容的低聚纳米粒子1-NPs的表面功能化，该纳米粒子具有近红外发射的CdTe/CDS量子点和叶酸，用于体内肿瘤靶向成像。利用1-NPs上半胱氨酸残基的-NH2和-SH基团共价偶联CdTe/CDS量子点和Mal-Fas，制备了杂化纳米粒子1-NPs-Qds-FA。制备的1-NPs-QDS-FA在734 nm处有近红外荧光发射，在体外可被高表达FR的肿瘤细胞选择性摄取，在体内可选择性摄取高表达的FR。这是低聚/无机杂化纳米粒子的第一个例子，为人们提供了高选择性的肿瘤靶向成像的新型生物材料。
We report herein the facile surface-functionalization of one type of biocompatible, oligomeric nanoparticles1-NPswith NIR-emitting CdTe/CdS QDs and folate for tumor-targeted imagingin vivo. The –NH2and –SH groups of cysteine residues on the1-NPswere utilized to covalently conjugate CdTe/CdS QDs andMal-FAto prepare the hybrid nanoparticles1-NPs-QDs-FA. As-prepared1-NPs-QDs-FAshowed NIR-fluorescence emission at 734 nm, selective uptake by FR-overexpressing tumor cellsin vitro, and selective FR-overexpressing tumor-targeted imagingin vivo. This first example of oligomeric/inorganic hybrid nanoparticles provides people with new type of biomaterials for tumor-targeted imaging with high selectivity.