Increased Urine and Serum Nerve Growth Factor Levels in Interstitial Cystitis Suggest Chronic Inflammation Is Involved in the Pathogenesis of Disease
Increased Urine and Serum Nerve Growth Factor Levels in Interstitial Cystitis Suggest Chronic Inflammation Is Involved in the Pathogenesis of Disease
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DOI：
10.1371/journal.pone.0044687
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发表时间：
2012-09-17
期刊：
影响因子：
3.7
通讯作者：
Kuo, Hann-Chorng
中科院分区：
文献类型：
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作者：
Liu, Hsin-Tzu;Kuo, Hann-Chorng
目的：间质性膀胱炎/膀胱疼痛综合征（IC/BPS）是一种由局部慢性炎症引起的膀胱疾病。本研究旨在探讨IC/BPS患者血清和尿液中神经生长因子（NGF）的水平。材料与方法：选择IC/BPS患者30例，正常对照组28例。IC/BPS的诊断依据是频率、膀胱疼痛和膀胱镜水扩张时肾小球的存在。在给予任何治疗前收集血清和尿液。结果：IC/PBS组患者的尿NGF水平（26.3 +/- 11.2 pg/ml）显著高于对照组（1.40 +/- 0.63 pg）（p = 0.014）。正常化后，IC/BPS组的尿NGF/Cr水平（0.69 ± 0.38 pg/mg）显著高于对照组（0.20 ± 0.01，p = 0.011）。相对于对照受试者的水平（1.90 +/- 0.38 pg/mL），IC/BPS患者的平均血清NGF水平更高（3.48 +/- 0.55 pg/mL）（p = 0.015）。IC/BPS患者血、尿NGF水平无明显相关性。然而，IC/BPS患者的临床特征和医疗共病并没有表现出显着的差异与较高和较低的血清NGFlevel.Conclusions：IC/BPS患者尿中的神经生长因子水平升高，表明慢性炎症参与这种膀胱疾病。半数以上IC/BPS患者循环血中NGF水平升高，但尿和血中NGF无相关性，血清中NGF升高与临床特征无关。
Objective: Interstitial cystitis/bladder pain syndrome (IC/BPS) is considered a bladder disorder due to localized chronic inflammation. This study investigated the nerve growth factor (NGF) levels in serum and urine in patients with IC/BPS.Materials and Methods: Thirty patients with IC/BPS and 28 normal subjects without lower urinary tract symptoms were recruited from an outpatient clinic. IC/BPS was diagnosed by frequency, bladder pain, and the presence of glomerulations during cystoscopic hydrodistention. Serum and urine were collected before any treatment was given. Serum NGF and urinary NGF/Cr levels were compared between IC/BPS and the controls.Results: Urinary NGF levels were significantly higher in patients with IC/PBS (26.3 +/- 11.2 pg/ml) than in controls (1.40 +/- 0.63 pg) (p = 0.014). After normalization, the urinary NGF/Cr levels were significantly greater in IC/BPS (0.69 +/- 0.38 pg/mg) than controls (0.20 +/- 0.01, p = 0.011). Relative to the levels in control subjects (1.90 +/- 0.38 pg/mL), the mean serum NGF levels were higher in patients IC/BPS patients (3.48 +/- 0.55 pg/mL) (p = 0.015). No significant correlation was found between the serum and urinary NGF levels in IC/BPS patients. However, the clinical characteristics and medical co-morbidities did not show significant difference between IC/BPS patients with a higher and lower serum NGF level.Conclusions: Increased urinary NGF levels in IC/BPS patients suggest that chronic inflammation is involved in this bladder disorder. Increased circulating serum NGF levels were noted in over half of patients with IC/BPS, however, the urinary and serum NGF were not inter-correlated and elevated serum NGF did not relate with clinical features.