Challenging role of Wnt5a and its signaling pathway in cancer metastasis (Review).
Challenging role of Wnt5a and its signaling pathway in cancer metastasis (Review).
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DOI：
10.3892/etm.2014.1676
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发表时间：
2014-07
影响因子：
2.7
通讯作者：
Liao D
中科院分区：
文献类型：
--
作者：
Zhu N;Qin L;Luo Z;Guo Q;Yang L;Liao D
Wnt 5a是无翅相关/小鼠乳腺肿瘤病毒整合家族的非经典信号成员，其参与广泛的细胞过程，特别是在癌症发展和转移中。越来越多的证据表明，Wnt 5a在各种类型的癌症转移中表现出矛盾的作用。因此，癌症转移中的Wnt 5a信号级联似乎是复杂的，并且可能依赖于结合受体、下游效应物、外源性抑制剂和肿瘤微环境，以及细胞外基质，特别是细胞/组织嗜性环境。本研究的目的是总结以往的研究结果的Wnt 5a的作用和各种类型的癌症转移的潜在机制。此外，有理由假设Wnt 5a及其相关信号通路可能成为治疗癌症转移的分子靶点。
Wnt5a is a noncanonical signaling member of the wingless-related/mouse mammary tumor virus integration family, which is involved in a wide range of cellular processes, particularly in cancer development and metastasis. Accumulating evidence indicates that Wnt5a exhibits paradoxical effects in various types of cancer metastasis. Therefore, the Wnt5a signaling cascade in cancer metastasis appears to be complex and may depend on binding receptors, downstream effectors, exogenous inhibitors and tumor microenvironments, as well as the extracellular matrix, particularly cell/tissue-tropic contexts. The aim of the present study was to summarize the previous findings on the roles of Wnt5a and the potential mechanisms in various types of cancer metastasis. Furthermore, it is reasonable to hypothesize that Wnt5a and the involved signaling pathways may become molecular targets in the treatment of cancer metastasis.
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