Bright liver and alanine aminotransferase are associated with metabolic syndrome in adults
Bright liver and alanine aminotransferase are associated with metabolic syndrome in adults
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DOI：
10.1038/oby.2005.147
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发表时间：
2005-07-01
期刊：
影响因子：
--
通讯作者：
Huang, KC
中科院分区：
文献类型：
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作者：
Shen, YH;Yang, WS;Huang, KC
目的：代谢综合征已成为世界性的重大健康问题。在这项研究中，我们调查了看似健康的成年人的代谢综合征、超声(US)光明肝(BL)和血浆丙氨酸氨基转移酶(ALT)水平之间的关系。研究方法和步骤：2000年从台湾四个全国性的MJ健康筛查中心招募了15,430名无酒精且无乙型或丙型肝炎的健康成年人。代谢综合征的定义使用国家胆固醇教育小组(NCEP)代谢综合征标准或修改后的NCEP标准。根据肝脏超声，受试者被分为有无肝细胞瘤两组。结果：发生代谢综合征的粗OR为13.92(按改良NCEP标准为12.19)，年龄-BMI-性别调整后OR为3.77(按改良NCEP标准为3.71)。在ALT水平升高的受试者中，代谢综合征的OR显著高于ALT水平正常的受试者。在调整了年龄、性别和BMI后，BL和ALT水平升高与代谢综合征的风险增加独立相关。讨论：在成年人中，存在BL和血浆ALT水平升高与代谢综合征的风险增加独立相关。这些因素促成了一份知名的名单。风险因素，包括肥胖、年龄和男性，因此可以在临床环境中作为代谢综合征的额外评估。
Objectives: The metabolic syndrome has become a significant health problem worldwide. In this study, we investigated the relationship between the metabolic syndrome, bright liver (BL) by ultrasonography (US), and plasma alanine aminotransferase (ALT) levels among apparently healthy adults.Research Methods and Procedures: A total of 15,430 nonalcoholic healthy adults without hepatitis B or C were recruited from four nationwide MJ Health Screening Centers in Taiwan in 2000. Metabolic syndrome was defined using the National Cholesterol Education Panel (NCEP) metabolic syndrome criteria or modified NCEP criteria. Based on liver US, subjects were classified into either having BL or not. The relationship between the metabolic syndrome, BL, and ALT levels was examined using multivariate logistic regression analysis.Results: The crude OR of the metabolic syndrome was 13.92 (12.19 using modified NCEP criteria), and the age-BMI-sex-adjusted OR was 3.77 (3.71 using modified NCEP criteria) in subjects with BL vs. subjects without BL, respectively. The ORs of the metabolic syndrome were significantly higher in subjects with elevated ALT levels than in those with normal ALT levels. After adjustment for age, sex, and BMI, BL and elevated ALT level were independently associated with increased risk of the metabolic syndrome.Discussion: Presence of BL and elevated plasma ALT level was independently associated with increased risk of the metabolic syndrome in adults. These factors contribute to a list of well-known. risk factors, including obesity, aging, and male sex, and thus can be applied as an additional evaluation for the metabolic syndrome in a clinical setting.