DEMONSTRATION OF AN ASSOCIATION AMONG DIETARY-CHOLESTEROL, CENTRAL SEROTONERGIC ACTIVITY, AND SOCIAL-BEHAVIOR IN MONKEYS
DEMONSTRATION OF AN ASSOCIATION AMONG DIETARY-CHOLESTEROL, CENTRAL SEROTONERGIC ACTIVITY, AND SOCIAL-BEHAVIOR IN MONKEYS
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DOI：
10.1097/00006842-199411000-00001
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发表时间：
1994-11-01
影响因子：
3.3
通讯作者：
MANN, JJ
中科院分区：
文献类型：
--
作者：
KAPLAN, JR;SHIVELY, CA;MANN, JJ
流行病学研究将血浆胆固醇降低与自杀、暴力和事故导致的死亡率命运增加联系起来。中枢5-羟色胺能活动不足同样与暴力和自杀行为有关。我们调查了饮食和血浆胆固醇、社会行为和5-羟色胺系统之间的关系，作为对这些发现的可能解释。幼年食蟹猴(8只雌性和9只雄性)被喂以高脂肪和高或低胆固醇的饮食。然后，我们在8个月的时间里评估了他们的行为。在行为观察开始后4个月和5.5个月，两次评估血脂和脑脊液中5-羟色胺、去甲肾上腺素和多巴胺的代谢产物。与高胆固醇饮食的动物相比，食用低胆固醇饮食的动物更具攻击性，从属关系更少，脑脊液中5-羟基吲哚乙酸的浓度更低(p<；各0.05)。饮食胆固醇、5-羟色胺能活性和社会行为之间的联系与来自其他物种和实验的数据一致，并表明饮食脂质可以影响大脑神经化学和行为；这一现象可能与我们对在降低胆固醇试验中观察到的自杀和暴力相关死亡增加的理解有关。关键词：短尾猴，营养进化。
Epidemiologic studies link plasma cholesterol reduction to increased mortality fates as a result of suicide, violence, and accidents. Deficient central serotonergic activity is similarly associated with Violence and suicidal behavior. We investigated the relationship among dietary and plasma cholesterol, social behavior, and the serotonin system as a possible explanation for these findings. juvenile cynomolgus monkeys (eight female and nine male) were fed a diet high in fat and either high or low in cholesterol. We then evaluated their behavior over an 8-month period. Plasma lipids and cerebrospinal fluid metabolites of serotonin, norepinephrine, and dopamine were assessed on two occasions, at 4 and 5.5 months after the initiation of behavioral observations. Animals that consumed a low-cholesterol diet were more aggressive, less affiliative, and had lower cerebrospinal fluid concentrations of 5-hydroxyindoleacetic acid than did their high-cholesterol counterparts (p < .05 for each). The association among dietary cholesterol, serotonergic activity, and social behavior was consistent with data from other species and experiments and suggested that dietary lipids can influence brain neurochemistry and behavior; this phenomenon could be relevant to our understanding of the increase in suicide and violence-related death observed in cholesterol-lowering trials. Key words: Macaca fascicularis, nutritional evolution.