The prevalence of primary open-angle glaucoma in Japanese - The Tajimi study
The prevalence of primary open-angle glaucoma in Japanese - The Tajimi study
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DOI：
10.1016/j.ophtha.2004.03.029
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发表时间：
2004-09-01
期刊：
影响因子：
13.7
通讯作者：
Kitazawa, Y
中科院分区：
文献类型：
--
作者：
Iwase, A;Suzuki, Y;Kitazawa, Y
目的：评估日本中部多见市原发性开角型青光眼（POAG）的患病率及其与眼内压（IOP）的关系。设计：在特定人群中进行的横断面流行病学研究。参与者：从多见市40岁以上人群中随机选择的受试者。干预：每例受试者接受筛选检查，包括面谈和眼科检查，包括通过Goldmann压平眼压计测量IOP，中央角膜厚度（CCT）、裂隙灯检查、眼底照相和使用倍频技术的筛选视野测试。当怀疑有眼部疾病时，受试者被转诊接受明确检查。在确定性检查期间，进行了裂隙灯检查、IOP测量、使用Humphrey Field Analyzer 30-2 SITA标准程序（Humphrey Instruments，圣莱安德罗，加利福尼亚州）进行的视野测试、视盘和眼底检查以及前房角镜检查，并获得了立体椎间盘照片。青光眼的诊断是根据视盘外观，周边的结果，和其他眼部findings.Main Outcome Measures：POAG的患病率，平均眼压，平均CCT.Results：3870合格的人，3021（78.1%）参加了这项研究。40岁以上人群中POAG的估计患病率为3.9%（95%置信区间[CI]，3.2%-4.6%）。IOP水平≤ 21 mmHg的POAG病例的患病率为3.6%（95% CI，2.9%-4.3%），而IOP水平> 21 mmHg的POAG病例的患病率为0.3%（95% CI，0.1%-0.5%）。POAG患者的平均眼压为15.4 ± 2.8右眼（n = 115）和左眼（n = 115）分别为15.2+/-2.8 mmHg（标准差），显著高于非青光眼受试者（右眼14.5 ± 2.5 mmHg; n = 2759; P = 0.0004;左眼14.4 ± 2.6 mmHg; n = 2757; P = 0.0026）。眼压水平为21 mmHg或更低的POAG眼的平均CCT在右眼为518 ± 29（n = 109），在左眼为519 ± 29 Am（n=110），与非青光眼眼的水平无显著差异（520+/-32 mum [n=2690]; 522+/-32 mum [n = 2692]; P>0.05）。结论：该人群POAG的患病率为3.9%。92%的POAG患者眼压≤ 21 mmHg。
Purpose: To assess the prevalence of primary open-angle glaucoma (POAG) and its association with intraocular pressure (IOP) in Tajimi City in central Japan.Design: A cross-sectional epidemiologic study in a defined population.Participants: Subjects randomly selected from the population older than 40 years in Tajimi City.Intervention: Each subject underwent a screening examination comprised of an interview and ophthalmic examinations, including measurement of IOP by a Goldmann applanation tonometer, central corneal thickness (CCT), slit-lamp examination, fundus photography, and a screening visual field test using frequency doubling technology. When ocular diseases were suspected, the subjects were referred for definitive examination. During the definitive examination, slit-lamp examination, IOP measurement, a visual field test using Humphrey Field Analyzer 30-2 SITA Standard program (Humphrey Instruments, San Leandro, CA), optic disc and fundus examination, and gonioscopy were performed and stereoscopic disc photographs were obtained. A diagnosis of glaucoma was made based on optic disc appearance, perimetric results, and other ocular findings.Main Outcome Measures: Prevalence of POAG, mean IOP, and mean CCT.Results: Of 3870 eligible people, 3021 (78.1%) participated in the study. The estimated prevalence of POAG in the population older than 40 years was 3.9% (95% confidence interval [CI]), 3.2%-4.6%). The prevalence of cases of POAG with IOP levels of 21 mmHg or less was 3.6% (95% CI, 2.9%-4.3%), whereas the prevalence for those with IOP levels of more than 21 mmHg was 0.3% (95% CI, 0.1%-0.5%). The average IOP for eyes with POAG was 15.4+/-2.8 (standard deviation) in the right eye (n = 115) and 15.2+/-2.8 mmHg in the left eye (n = 115), which was significantly higher than that of nonglaucoma subjects (14.5+/-2.5 in the right eye; n = 2759; P = 0.0004; and 14.4+/-2.6 mmHg in the left eye; n = 2757; P = 0.0026). The mean CCT of POAG eyes with IOP levels of 21 mmHg or less was 518+/-29 (n = 109) in the right eye and 519 29 Am (n=110) in the left eye, levels that were not significantly different from that of nonglaucoma eyes (520+/-32 mum [n=2690]; and 522+/-32 mum [n = 2692]; P>0.05).Conclusions: The prevalence of POAG in this population was 3.9%. In 92% patients with POAG, the IOP was 21 mmHg or less.