Efficacy of azithromycin and rifabutin in preventing infection by Mycobacterium avium complex in beige mice.
Efficacy of azithromycin and rifabutin in preventing infection by Mycobacterium avium complex in beige mice.
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阿奇霉素和利福布丁预防米色小鼠鸟分枝杆菌复合体感染的功效。
DOI：
10.1093/jac/36.4.641
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Young,LS
中科院分区：
文献类型：
--
作者：
Bermudez,LE;Petrofsky,M;Inderlied,CB;Young,LS
我们研究了氮杂内酯、阿奇霉素和利福昔单抗预防米色小鼠鸟分枝杆菌复合群（MAC）播散性感染的潜力。在用108 cfu MAC经口攻击小鼠之前6天，通过管饲法给予阿奇霉素200 mg/kg、利福贝胺（30 mg/kg或60 mg/kg），并且此后每天持续10天，在此期间，小鼠在隔天（第+1、+3、+5、+7和+9天）再次用相同的接种物攻击。64天后，估计血液中细菌的存在以及肝、脾和阑尾中活菌的数量。阿奇霉素和60 mg/kg/天的利福贝胺治疗显著降低了菌血症的发生率和阑尾中的细菌数量，但30 mg/kg/天的治疗没有显著降低。阿奇霉素给药导致肝脏和脾脏的MAC显著减少，但阑尾中的MAC没有减少，而60 mg/kg利福贝胺则相反。我们的研究结果表明，阿奇霉素和利福霉素都可以预防MAC播散性感染，但氮杂内酯在减少感染负担方面比利福霉素更有效。
We investigated the potential of the azalide, azithromycin, and rifabutin in preventing disseminated infection due toMycobacterium aviumcomplex (MAC) in beige mice. Azithromycin 200 mg/kg, rifabutin (30 mg/kg or 60 mg/kg) were administered by gavage 6 days before mice were challenged orally with 108cfu MAC and daily for 10 days thereafter during which time the mice were again challenged with the same inoculum on alternate days (days +1, +3, +5, +7, and +9). Sixty-four days later, the presence of bacteria in the blood and the number of viable bacteria in liver, spleen and appendix were estimated. Treatment with azithromycin and 60 mg/kg/day rifabutin but not 30 mg/kg/day, significantly decreased the incidence of bacteraemia and the number of bacteria in the appendix. The administration of azithromycin resulted in significantly fewer MAC in the liver and spleen but not in the appendix whereas the converse was true of 60 mg/kg rifabutin. Our results indicate that both azithromycin and rifabutin can prevent MAC disseminated infection, but that the azalide is more effective than the rifamycin in reducing the burden of infection.