Microbe-induced cytoplasmic incompatibility as a mechanism for introducing transgenes into arthropod populations
Microbe-induced cytoplasmic incompatibility as a mechanism for introducing transgenes into arthropod populations
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DOI：
10.1046/j.1365-2583.1999.820243.x
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发表时间：
1999-05-01
影响因子：
2.6
通讯作者：
Hoffmann, AA
中科院分区：
文献类型：
--
作者：
Turelli, M;Hoffmann, AA
许多节肢动物感染了母体传播的沃尔巴克氏体细胞内细菌。当未感染的雌性与受感染的雄性交配或携带不同沃尔巴克氏体菌株的雄性和雌性交配时，这些感染通常会产生“细胞质不相容性”（CI），从而降低卵孵化频率。因为受感染的女性通常享有健康优势——她们可以有效地免受携带相同沃尔巴克氏体菌株的男性的任何影响——沃尔巴克氏体和相关的细胞质成分可以在自然群体中迅速传播。因此，沃尔巴克氏体可能会将与疾病控制或害虫消除相关的转基因引入人群。本文对“CI 驱动”的三种替代策略进行了简单的数学分析。这些分析揭示了必须估计哪些参数才能预测种群动态，并且它们证明了在目标种群中最初驱动和/或维持转基因的严格要求。
Many arthropods are infected with maternally transmitted, intracellular bacteria of the genus Wolbachia. These infections often produce 'cytoplasmic incompatibility' (CI)-reduced egg-hatch frequencies when uninfected females mate with infected males or when males and females carrying different Wolbachia strains mate. Because infected females often enjoy a fitness advantage-they are effectively immune to any effects from males carrying the same Wolbachia strain-Wolbachia and associated cytoplasmic elements can spread rapidly through natural populations. Wolbachia might therefore drive transgenes associated with disease control or pest abatement into populations. In this paper, simple mathematical analyses are presented of three alternative strategies for 'CI drive'. The analyses reveal which parameters must be estimated in order to predict population dynamics, and they demonstrate stringent requirements for initially driving and/or maintaining transgenes in target populations.