Simultaneous in vivo dynamic contrast-enhanced magnetic resonance and scintigraphic imaging
Simultaneous in vivo dynamic contrast-enhanced magnetic resonance and scintigraphic imaging
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DOI：
10.1088/0031-9155/56/4/n02
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发表时间：
2011-02-21
影响因子：
3.5
通讯作者：
Nalcioglu, Orhan
中科院分区：
文献类型：
--
作者：
Hamamura, Mark J.;Roeck, Werner W.;Nalcioglu, Orhan
在这项研究中，我们研究了一种集成的小动物磁共振（MR）和伽马射线成像系统的体内应用，该系统由半导体辐射探测器、平行孔准直器和专用射频线圈组成。Gadodiamide和Tc-99m sestimbi同时注射到小鼠体内，同时获得肾脏动态对比增强MR和ct图像。磁共振信号强度和放射性的时间曲线显示药物的快速吸收，随后是更缓慢的排泄，与先前报道的文献一致。我们的结果证明了同时使用磁共振造影剂和放射性示踪剂测量多个生物过程的可行性。
In this study, we investigated the in vivo application of an integrated small-animal magnetic resonance (MR) and gamma-ray imaging system that consists of a semiconductor-based radiation detector, a parallel-hole collimator, and a specialized radiofrequency coil. Gadodiamide and Tc-99m sestimibi agents were injected simultaneously into a mouse, and simultaneous dynamic contrast-enhanced MR and scintigraphic images of the kidneys were acquired. The time curves of both the MR signal intensity and radioactivity indicate a rapid uptake of the agents followed by a more gradual excretion, consistent with the previously reported literature. Our results demonstrate the feasibility of measuring multiple biological processes at the same time using both MR contrast agents and radiotracers.