Long-term structural changes in pH-sensitive hydrogels.
Long-term structural changes in pH-sensitive hydrogels.
复制标题
pH 敏感水凝胶的长期结构变化。
DOI：
10.1016/0142-9612(91)90071-h
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发表时间：
1991
期刊：
影响因子：
14
通讯作者：
Siegel,RA
中科院分区：
文献类型：
--
作者：
DeMoor,CP;Doh,L;Siegel,RA
The long-term swelling properties of lightly cross-linked copolymer hydrogels consisting of methyl methacrylate (MMA) andN,N-dimethylaminoethyl methacrylamide (DMAA) were studied as a function of pH at 25°C and 37°C. In acidic pH regions, the swelling equilibria were found to be stable over 200 d. In alkaline pH environments, however, the ‘equilibrium’ swelling increases slowly with time. Gas chromatography of the supernatant shows that substantial methanol is produced, along with trace amounts ofN,N-dimethylethylene diamine. Thus, the primary mechanism underlying the structural changes appears to be hydrolysis of ester groups in the MMA side-chains, with a much smaller contribution due to amidolysis of the DMAA side-chains. The implications of these structural changes for the application of this hydrogel, as well as other related hydrogels as long-term implantable biomaterials, are discussed.
