Error-related Alpha Suppression: Scalp Topography and (Lack of) Modulation by Modafinil.
Error-related Alpha Suppression: Scalp Topography and (Lack of) Modulation by Modafinil.
复制标题
错误相关的阿尔法抑制：头皮地形和莫达非尼（缺乏）调节。
DOI：
10.1162/jocn_a_01836
复制
发表时间：
2022
影响因子：
3.2
通讯作者：
Pizzagalli,DiegoA
中科院分区：
文献类型：
--
作者：
Schroder,HansS;Iturra-Mena,AnnM;Breiger,Micah;Linton,SamanthaR;Robble,MykelA;Kangas,BrianD;Bergman,Jack;Nickels,Stefanie;Vitaliano,Gordana;Der-Avakian,Andre;Barnes,SamuelA;Carlezon,WilliamA;Pizzagalli,DiegoA
表现中的错误会引发认知和神经变化，这些变化是为了适应性地适应不断变化的需求而实施的。错误相关阿尔法抑制（ERAS）——指错误反应后阿尔法频段的功率下降——被认为反映了错误后的认知唤醒。然而，这项工作大部分都是相关的，并且没有对其药理学敏感性进行直接研究。在研究 1 (n= 61) 中，我们在专门为跨物种评估开发的新型侧翼任务中评估了 ERAS 的存在和头皮分布。研究 2 (n= 26) 采用安慰剂对照受试者内设计，使用相同的任务，评估了 ERAS 对安慰剂 (0 mg)、低剂量 (100 mg) 和高剂量 (200 mg) 莫达非尼（一种觉醒促进剂）的敏感性。与之前的工作一致，两项研究中 ERAS 在顶枕记录部位达到最大。在研究2中，莫达非尼对ERAS没有很强的影响（出现了显着的准确性×剂量相互作用，但在校正多重比较后药物与安慰剂的差异没有达到统计学显着性，并且在控制准确率后不存在）。在这两项研究中，ERAS 与准确率相关。因此，莫达非尼并没有像假设的那样影响 ERAS，研究结果表明 ERAS 可能反映了对罕见事件的定向反应。
Errors in performance trigger cognitive and neural changes that are implemented to adaptively adjust to fluctuating demands. Error-related alpha suppression (ERAS)—which refers to decreased power in the alpha frequency band after an incorrect response—is thought to reflect cognitive arousal after errors. Much of this work has been correlational, however, and there are no direct investigations into its pharmacological sensitivity. In Study 1 (n= 61), we evaluated the presence and scalp distribution of ERAS in a novel flanker task specifically developed for cross-species assessments. Using this same task in Study 2 (n= 26), which had a placebo-controlled within-subject design, we evaluated the sensitivity of ERAS to placebo (0 mg), low (100 mg), and high (200 mg) doses of modafinil, a wakefulness promoting agent. Consistent with previous work, ERAS was maximal at parieto-occipital recording sites in both studies. In Study 2, modafinil did not have strong effects on ERAS (a significant Accuracy × Dose interaction emerged, but drug–placebo differences did not reach statistical significance after correction for multiple comparisons and was absent after controlling for accuracy rate). ERAS was correlated with accuracy rates in both studies. Thus, modafinil did not impact ERAS as hypothesized, and findings indicate ERAS may reflect an orienting response to infrequent events.