Carbon Dots for Heavy-Metal Sensing, pH-Sensitive Cargo Delivery, and Antibacterial Applications
Carbon Dots for Heavy-Metal Sensing, pH-Sensitive Cargo Delivery, and Antibacterial Applications
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DOI：
10.1021/acsanm.0c02305
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发表时间：
2020-12-24
影响因子：
5.9
通讯作者：
Gedanken, Aharon
中科院分区：
文献类型：
--
作者：
Das, Poushali;Maruthapandi, Moorthy;Gedanken, Aharon
目前，利用废物制造创新有用材料的技术已经取得了显著的进步。出于同样的目的，对被称为黄麻工业废料的黄麻球童的利用提出了一种可能的可持续方法。以工业废渣为原料，采用声化学方法制备了碳点（CDs），然后用苯扎氯铵（BZC）对其表面进行改性，得到了黄麻衍生的荧光表面季铵化CDs (JB-CDs)，该CDs具有优异的水溶性、激发依赖性发射和良好的光稳定性，可作为荧光纳米开关检测水溶液中的无机污染物，如铬（VI） [Cr(VI)]离子。与被测的其他金属离子和生物分子相比，JB-CDs可以通过发光猝灭（“关闭”）检测低至0.03 μ M的Cr（VI）浓度，并进一步选择性地恢复荧光（“打开”）以检测抗坏血酸（AA）。该方法在实际应用中具有响应时间快、选择性和灵敏度高的优点。研究人员对一种革兰氏阴性细菌大肠杆菌和一种革兰氏阳性细菌金黄色葡萄球菌进行了抑菌试验，以证实其杀菌活性。结果表明，JB-CDs对细菌生长有明显的抑制作用。除此之外，在模型药物环丙沙星的释放研究中，job - cds起到了纳米载体的作用。研究发现，表面季铵盐化的JB-CDs具有pH响应释放行为，其中pH值为7.4时的释放行为比pH值为5.2和6.8时的释放行为更受控制。利用黄麻工业废料等可持续材料合成这种荧光纳米按钮、刺激反应药物释放和抗菌纳米材料，可以为智能多功能材料铺平道路。
Currently, the technologies accompanying the usage of waste materials for the fabrication of innovative useful materials have been significantly advanced. For the same purpose, a possible sustainable approach was demonstrated for the utilization of jute caddies, known as jute industry waste. From the industrial waste, carbon dots (CDs) were sonochemically prepared, followed by their surface modification with benzalkonium chloride (BZC) to yield waste jute-derived fluorescent surface-quaternized CDs (JB-CDs), which exhibit excellent water solubility, excitation-dependent emission, and good photostability, and were utilized as a fluorescent nanoswitch to detect inorganic pollutants, such as chromium (VI) [Cr(VI)] ions, in aqueous solutions. JB-CDs can detect Cr(VI) concentrations as low as 0.03 mu M through luminescence quenching ("turn-off") and further recover their fluorescence ("turn-on") selectively for sensing ascorbic acid (AA), compared with other metal ions and biomolecules tested. The present technique has the advantages of fast response time and high selectivity and sensitivity in practical applications. JB-CDs were tested against a Gram-negative bacterium, Escherichia coli, and a Gram-positive bacterium, Staphylococcus aureus, to confirm their bactericidal activity. The results indicated that JB-CDs substantially inhibited the growth of the tested bacteria. Besides this, JB-CDs played the role of a nanovehicle to exemplify the release study of a model drug ciprofloxacin. It was observed that the surface-quaternized JB-CDs showed a pH-responsive release behavior, where the release behavior was found to be better controlled at pH 7.4 than at pH 5.2 and 6.8. The synthesis of such a fluorescent nanobutton, stimuli-responsive drug release, and antibacterial nanomaterial using a sustainable material such as jute industrial waste can pave the path for a smart multifunctional material.