Circadian and genetic effects on ethanol elimination in LS and SS mice.
Circadian and genetic effects on ethanol elimination in LS and SS mice.
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昼夜节律和遗传对 LS 和 SS 小鼠乙醇消除的影响。
DOI：
10.1111/j.1530-0277.1982.tb04989.x
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Collins,AC
中科院分区：
文献类型：
--
作者：
Gilliam,DM;Collins,AC
行为学研究表明，小鼠对乙醇的反应受到昼夜节律的影响。研究可能的昼夜节律对乙醇消除的影响是模糊的，是否消除的变化有助于昼夜节律变化的反应。因此，对长睡眠（LS）和短睡眠（SS）雄性小鼠在0300、0900、1500或2100小时腹腔注射2.5或4.1 g/kg乙醇后血液酒精浓度（BACs）的线性下降进行了评估。在两种乙醇剂量下，LS小鼠的总体平均BAC显著高于SS小鼠。当剂量为4.1 g/kg时，2100小时的LS平均BAC高于0900小时。两系小鼠在0300和0900小时的清除率均高于1500和2100小时。在此剂量下，SS小鼠的BAC一般比LS小鼠下降得更快。在2.5 g/kg剂量下，两系小鼠在0900小时的下降速度都快于2100小时。与LS小鼠相比，SS小鼠表现出更大的总体下降率。血液酒精浓度和消除率的品系差异可能是由用于选择这些小鼠的剂量变化引起的，并可能有助于对乙醇反应的昼夜节律影响。
Behavioral studies using mice have suggested circadian influences on response to ethanol. Studies examining possible circadian influences on ethanol elimination are ambiguous as to whether changes in elimination contribute to circadian variations in response. Therefore, the linear declines in blood alcohol concentrations (BACs) were assessed in long‐sleep (LS) and short‐sleep (SS) male mice at 0300, 0900, 1500, or 2100 hr following an intraperitoneal injection of either 2.5 or 4.1 g/kg ethanol. Overall mean BAC for LS mice was significantly higher than for SS mice at both ethanol doses. With the 4.1 g/kg dose, LS mean BAC was higher at 2100 hr than at 0900 hr. Both lines of mice exhibited faster elimination rates at 0300 and 0900 hr than at 1500 and 2100 hr. SS mice generally showed a more rapid decline in BAC than did LS mice at this dose. With the 2.5 g/kg dose, the rate of decline was faster at 0900 hr than at 2100 hr for both lines of mice. SS mice showed a significantly greater overall rate of decline than did LS mice. The line differences in blood alcohol concentration and elimination rate may have resulted from a change in the doses used to select these mice and may contribute to circadian influences on ethanol response.